Incidence and risk factors for tenofovir-associated nephrotoxicity among human immunodeficiency virus-infected patients in Korea
Background/Aims Little is known about tenofovir disoproxil fumarate (TDF)-induced nephrotoxicity in human immunodeficiency virus (HIV)-infected patients in Korea. The objective of this study was to evaluate the incidence and risk factors of TDF-associated nephrotoxicity among HIV-infected patients i...
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doaj-525b215e4bbe4b2a9ba1151d1720a5f52021-08-10T00:20:27ZengThe Korean Association of Internal MedicineThe Korean Journal of Internal Medicine1226-33032005-66482019-03-0134240941710.3904/kjim.2016.418169909Incidence and risk factors for tenofovir-associated nephrotoxicity among human immunodeficiency virus-infected patients in KoreaJeong Eun Lee0Shinwon Lee1Sang Heon Song2Ihm Soo Kwak3Sun Hee Lee4 Division of Infectious Disease, Department of Internal Medicine, Pusan National University Hospital, Busan, Korea Division of Infectious Disease, Department of Internal Medicine, Pusan National University Hospital, Busan, Korea Division of Nephrology, Department of Internal Medicine, Pusan National University Hospital, Busan, Korea Division of Nephrology, Department of Internal Medicine, Pusan National University Hospital, Busan, Korea Division of Infectious Disease, Department of Internal Medicine, Pusan National University Hospital, Busan, KoreaBackground/Aims Little is known about tenofovir disoproxil fumarate (TDF)-induced nephrotoxicity in human immunodeficiency virus (HIV)-infected patients in Korea. The objective of this study was to evaluate the incidence and risk factors of TDF-associated nephrotoxicity among HIV-infected patients in Korea. Methods A single-center retrospective cohort study was conducted on HIV-infected patients in Korea. We included patients who had started TDF or abacavir (ABC)-based antiretroviral therapy (ART) between October 2006 and December 2014. Estimated glomerular filtration rate (eGFR) was estimated using the Chronic Kidney Disease-Epidemiology Collaboration equation. Renal dysfunction was defined as > 25% decrease of baseline eGFR. A propensity matched case-control study was conducted to compare renal dysfunction rates between the two groups. The risk factors of nephrotoxicity were analyzed by Cox regression analysis. Results A total of 210 HIV-infected patients were included in the study, of which, 108 were TDF-based ART group and 102 were ABC-based ART group. Renal dysfunction occurred in 16 patients (14.8%) in the TDF group and 11 (10.8%) in the ABC group. Incidence of renal dysfunction of TDF and ABC group was 9.66 per 100 person-years (PYs) and 5.14 per 100 PYs, respectively (p = 0.176). In propensity-score-matched analysis, renal dysfunction rates were TDF 13.3% versus ABC 13.3% (p > 0.999). In multivariable analysis, Centers for Disease Control and Prevention clinical category C was a significant risk factor for renal dysfunction. Conclusions Approximately, 13% of HIV-infected patients treated with TDF had renal dysfunction. Advanced stage of HIV infection was a significant risk factor for renal dysfunction.http://www.kjim.org/upload/pdf/kjim-2016-418.pdftenofovirhiv-infected patientsnephrotoxicitycenters for disease control and prevention clinical category c |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jeong Eun Lee Shinwon Lee Sang Heon Song Ihm Soo Kwak Sun Hee Lee |
spellingShingle |
Jeong Eun Lee Shinwon Lee Sang Heon Song Ihm Soo Kwak Sun Hee Lee Incidence and risk factors for tenofovir-associated nephrotoxicity among human immunodeficiency virus-infected patients in Korea The Korean Journal of Internal Medicine tenofovir hiv-infected patients nephrotoxicity centers for disease control and prevention clinical category c |
author_facet |
Jeong Eun Lee Shinwon Lee Sang Heon Song Ihm Soo Kwak Sun Hee Lee |
author_sort |
Jeong Eun Lee |
title |
Incidence and risk factors for tenofovir-associated nephrotoxicity among human immunodeficiency virus-infected patients in Korea |
title_short |
Incidence and risk factors for tenofovir-associated nephrotoxicity among human immunodeficiency virus-infected patients in Korea |
title_full |
Incidence and risk factors for tenofovir-associated nephrotoxicity among human immunodeficiency virus-infected patients in Korea |
title_fullStr |
Incidence and risk factors for tenofovir-associated nephrotoxicity among human immunodeficiency virus-infected patients in Korea |
title_full_unstemmed |
Incidence and risk factors for tenofovir-associated nephrotoxicity among human immunodeficiency virus-infected patients in Korea |
title_sort |
incidence and risk factors for tenofovir-associated nephrotoxicity among human immunodeficiency virus-infected patients in korea |
publisher |
The Korean Association of Internal Medicine |
series |
The Korean Journal of Internal Medicine |
issn |
1226-3303 2005-6648 |
publishDate |
2019-03-01 |
description |
Background/Aims Little is known about tenofovir disoproxil fumarate (TDF)-induced nephrotoxicity in human immunodeficiency virus (HIV)-infected patients in Korea. The objective of this study was to evaluate the incidence and risk factors of TDF-associated nephrotoxicity among HIV-infected patients in Korea. Methods A single-center retrospective cohort study was conducted on HIV-infected patients in Korea. We included patients who had started TDF or abacavir (ABC)-based antiretroviral therapy (ART) between October 2006 and December 2014. Estimated glomerular filtration rate (eGFR) was estimated using the Chronic Kidney Disease-Epidemiology Collaboration equation. Renal dysfunction was defined as > 25% decrease of baseline eGFR. A propensity matched case-control study was conducted to compare renal dysfunction rates between the two groups. The risk factors of nephrotoxicity were analyzed by Cox regression analysis. Results A total of 210 HIV-infected patients were included in the study, of which, 108 were TDF-based ART group and 102 were ABC-based ART group. Renal dysfunction occurred in 16 patients (14.8%) in the TDF group and 11 (10.8%) in the ABC group. Incidence of renal dysfunction of TDF and ABC group was 9.66 per 100 person-years (PYs) and 5.14 per 100 PYs, respectively (p = 0.176). In propensity-score-matched analysis, renal dysfunction rates were TDF 13.3% versus ABC 13.3% (p > 0.999). In multivariable analysis, Centers for Disease Control and Prevention clinical category C was a significant risk factor for renal dysfunction. Conclusions Approximately, 13% of HIV-infected patients treated with TDF had renal dysfunction. Advanced stage of HIV infection was a significant risk factor for renal dysfunction. |
topic |
tenofovir hiv-infected patients nephrotoxicity centers for disease control and prevention clinical category c |
url |
http://www.kjim.org/upload/pdf/kjim-2016-418.pdf |
work_keys_str_mv |
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