Rodent model of disuse-induced bone loss by hind limb injection with botulinum toxin A

Rodent model of disuse-induced bone loss by hind limb injection with botulinum toxin A

Bone loss materializes rapidly after immobilization or mechanical unloading. Hind limb injection with botulinum toxin A (BTX) is a highly reproducible animal model for disuse-induced bone loss. Here we describe an easy-to-use and enhanced version of the method employing multiple hind limb injections...

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Bibliographic Details
Main Authors: Mikkel Bo Brent, Andreas Lodberg, Jesper Skovhus Thomsen, Annemarie Brüel
Format: Article
Language:English
Published: Elsevier 2020-01-01
Series:MethodsX
Subjects:
Bone loss
Osteopenia
Animal model
Disuse
Mechanical unloading
Online Access:http://www.sciencedirect.com/science/article/pii/S2215016120302995

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http://www.sciencedirect.com/science/article/pii/S2215016120302995

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