A 3D culture model of innervated human skeletal muscle enables studies of the adult neuromuscular junction

A 3D culture model of innervated human skeletal muscle enables studies of the adult neuromuscular junction

Two-dimensional (2D) human skeletal muscle fiber cultures are ill-equipped to support the contractile properties of maturing muscle fibers. This limits their application to the study of adult human neuromuscular junction (NMJ) development, a process requiring maturation of muscle fibers in the prese...

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Bibliographic Details
Main Authors: Mohsen Afshar Bakooshli, Ethan S Lippmann, Ben Mulcahy, Nisha Iyer, Christine T Nguyen, Kayee Tung, Bryan A Stewart, Hubrecht van den Dorpel, Tobias Fuehrmann, Molly Shoichet, Anne Bigot, Elena Pegoraro, Henry Ahn, Howard Ginsberg, Mei Zhen, Randolph Scott Ashton, Penney M Gilbert
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-05-01
Series:eLife
Subjects:
3D co-culture
neuromuscular junction
skeletal muscle
motor neuron
myasthenia gravis
acetylcholine receptor subunit epsilon
Online Access:https://elifesciences.org/articles/44530

Internet

https://elifesciences.org/articles/44530

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