Discordant Clinical Course of Vitamin-D-Hydroxylase (CYP24A1) Associated Hypercalcemia in Two Adult Brothers With Nephrocalcinosis

Discordant Clinical Course of Vitamin-D-Hydroxylase (CYP24A1) Associated Hypercalcemia in Two Adult Brothers With Nephrocalcinosis

Background/Aims: Hypercalcemia can result in nephrocalcinosis/nephrolithiasis and may lead to renal failure. Idiopathic infantile hypercalcemia is caused by mutations of the CYP24A1 gene, which regulates vitamin D activity. Classically infants present with hypercalcemia. Recently, a number of indivi...

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Bibliographic Details
Main Authors: Tilman Jobst-Schwan, Andrea Pannes, Karl Peter Schlingmann, Kai-Uwe Eckardt, Bodo B. Beck, Michael S. Wiesener
Format: Article
Language:English
Published: Karger Publishers 2015-08-01
Series:Kidney & Blood Pressure Research
Subjects:
Calcium metabolism
Hypercalciuria
Nephrolithiasis
Kidney stones
Hypervitaminosis
Online Access:http://www.karger.com/Article/FullText/368520

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