Optimal empiric treatment for KPC-2-producing Klebsiella pneumoniae infections in critically ill patients with normal or decreased renal function using Monte Carlo simulation

Optimal empiric treatment for KPC-2-producing Klebsiella pneumoniae infections in critically ill patients with normal or decreased renal function using Monte Carlo simulation

Abstract Background Limited clinical studies describe the pharmacodynamics of fosfomycin (FOS), tigecycline (TGC) and colistin methanesulfonate (CMS) in combination against KPC-producing Klebsiella pneumoniae (KPC-Kp). Population pharmacokinetic models were used in our study. Monte Carlo simulation...

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Bibliographic Details
Main Authors: Guoan Wang, Wei Yu, Yushan Cui, Qingyi Shi, Chen Huang, Yonghong Xiao
Format: Article
Language:English
Published: BMC 2021-03-01
Series:BMC Infectious Diseases
Subjects:
Population pharmacokinetics/pharmacodynamics model
Renal function
Tigecycline
Colistin methanesulfonate
Fosfomycin
KPC-2-producing Klebsiella pneumoniae
Online Access:https://doi.org/10.1186/s12879-021-06000-2

Internet

https://doi.org/10.1186/s12879-021-06000-2

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