Independent genomic polymorphisms in the PknH serine threonine kinase locus during evolution of the Mycobacterium tuberculosis Complex affect virulence and host preference.

Independent genomic polymorphisms in the PknH serine threonine kinase locus during evolution of the Mycobacterium tuberculosis Complex affect virulence and host preference.

Species belonging to the Mycobacterium tuberculosis Complex (MTBC) show more than 99% genetic identity but exhibit distinct host preference and virulence. The molecular genetic changes that underly host specificity and infection phenotype within MTBC members have not been fully elucidated. Here, we...

Full description

Bibliographic Details
Main Authors: Elena Mata, Damien Farrell, Ruoyao Ma, Santiago Uranga, Ana Belen Gomez, Marta Monzon, Juan Badiola, Alberto Anel, Jesús Gonzalo-Asensio, Carlos Martin, Stephen V Gordon, Nacho Aguilo
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-12-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1009061

Internet

https://doi.org/10.1371/journal.ppat.1009061

Similar Items