Sinomenine sensitizes multidrug-resistant colon cancer cells (Caco-2) to doxorubicin by downregulation of MDR-1 expression.

Sinomenine sensitizes multidrug-resistant colon cancer cells (Caco-2) to doxorubicin by downregulation of MDR-1 expression.

Chemoresistance in multidrug-resistant (MDR) cells over expressing P-glycoprotein (P-gp) encoded by the MDR1 gene, is a major obstacle to successful chemotherapy for colorectal cancer. Previous studies have indicated that sinomenine can enhance the absorption of various P-gp substrates. In the prese...

Full description

Bibliographic Details
Main Authors: Zhen Liu, Zhi-Jun Duan, Jiu-Yang Chang, Zhi-Feng Zhang, Rui Chu, Yu-Ling Li, Ke-Hang Dai, Guang-Quan Mo, Qing-Yong Chang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4047020?pdf=render

Internet

http://europepmc.org/articles/PMC4047020?pdf=render

Similar Items