Reduced bone mineral density in children with hypercalciuria, nephrolithiasis and nephrocalcinosis

• Main Authors: C. V. Maltsev, T. V. Mikhailova, S. S. Vinokurova
• Format: Article
• Language: Russian
• Published: Ltd. “The National Academy of Pediatric Science and Innovation” 2016-11-01
• Series: Rossijskij Vestnik Perinatologii i Pediatrii
• Subjects: children; hypercalciuria; nephrolithiasis; nephrocalcinosis; low bone mineral density
• Online Access: https://www.ped-perinatology.ru/jour/article/view/400

The article presents the results of a examination of 105 children aged 1 to 16 years, 22 of them are diagnosed with nephrocalcinosis, 11 stone in the urinary system amid hypercalciuria, 23 hypercalciuria was observed without the formation of concretions in the urinary system, 49 children with chronic pyelonephritis. In children with hypercalciuria, nephrolithiasis and nephrocalcinosis decreased bone mineral density was observed in 45% of cases, in children with chronic pyelonephritis osteopenia was found in half of the patients (51%). Reduced bone mineral density in children with hypercalciuria increased risk of fractures. In patients with osteopenia two-and three-multiples fractures were observed in 3 times more than the comparison group. Increase both of alkaline phosphatase and acidic phosphatase showed activation of bone metabolism, and proportionality of their activation determined state of bone mineral density. Patients with chronic pyelonephritis with severe osteopenia observed prepotency of processes of bone resorption relative to bone formation.