Attenuated Recovery of Contractile Function in Aging Hearts Following Global Ischemia/Reperfusion: Role of Extracellular HSP27 and TLR4

Abstract While cardiac functional recovery is attenuated in the elderly following cardiac surgery with obligatory global myocardial ischemia/reperfusion (I/R), the underlying mechanism remains incompletely understood. We observed previously that human and mouse myocardium releases heat shock protein...

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Bibliographic Details
Main Authors: Lihua Ao, Yufeng Zhai, Chunhua Jin, Joseph C Cleveland, David A Fullerton, Xianzhong Meng
Format: Article
Language:English
Published: BMC 2016-12-01
Series:Molecular Medicine
Online Access:http://link.springer.com/article/10.2119/molmed.2016.00204