Ovarian reserve of women with and without BRCA pathogenic variants: A systematic review and meta-analysis
Introduction: Preliminary clinical evidence suggests a detrimental effect of pathogenic variants of BRCA1 and 2 genes on fertility outcome. This meta-analysis evaluates whether women carrying BRCA mutations (BRCAm) have decreased ovarian reserve, in terms of Anti-Muellerian Hormone (AMH), compared t...
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doaj-54d73027e7f04a6fbb8294f62e7eda692021-10-09T04:36:58ZengElsevierBreast1532-30802021-12-0160155162Ovarian reserve of women with and without BRCA pathogenic variants: A systematic review and meta-analysisMaria Luisa Gasparri0Rosa Di Micco1Veronica Zuber2Katayoun Taghavi3Giampaolo Bianchini4Serena Bellaminutti5Francesco Meani6Rossella Graffeo7Massimo Candiani8Michael D. Mueller9Andrea Papadia10Oreste D. Gentilini11Department of Gynecology and Obstetrics, Ospedale Regionale di Lugano EOC, via tesserete 46, 6900 Lugano, Switzerland; Faculty of Biomedical Sciences, Università della Svizzera Italiana, via Giuseppe Buffi 13, 6900, Lugano, SwitzerlandBreast Surgical Unit, San Raffaele University Hospital, Milan, Italy; Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, ItalyBreast Surgical Unit, San Raffaele University Hospital, Milan, ItalyInstitute of Social and Preventive Medicine, University of Bern, Bern, SwitzerlandDepartment of Medical Oncology, San Raffaele University Hospital, Milan, ItalyDepartment of Gynecology and Obstetrics, Ospedale Regionale di Lugano EOC, via tesserete 46, 6900 Lugano, SwitzerlandDepartment of Gynecology and Obstetrics, Ospedale Regionale di Lugano EOC, via tesserete 46, 6900 Lugano, SwitzerlandInstitute of Oncology of Southern Switzerland (IOSI) and Breast Unit of Southern Switzerland (CSSI), Bellinzona, SwitzerlandDepartment of Gynecology and Obstetrics, San Raffaele University Hospital, Milan, ItalyDepartment of Obstetrics and Gynecology, University Hospital of Bern and University of Bern, Bern, SwitzerlandDepartment of Gynecology and Obstetrics, Ospedale Regionale di Lugano EOC, via tesserete 46, 6900 Lugano, Switzerland; Faculty of Biomedical Sciences, Università della Svizzera Italiana, via Giuseppe Buffi 13, 6900, Lugano, Switzerland; Corresponding author. Università della Svizzera Italiana (USI), Department of Gynecology and Obstetrics, Ente Ospedaliero Cantonale, Ospedale Regionale di Lugano, Lugano, Switzerland.Breast Surgical Unit, San Raffaele University Hospital, Milan, ItalyIntroduction: Preliminary clinical evidence suggests a detrimental effect of pathogenic variants of BRCA1 and 2 genes on fertility outcome. This meta-analysis evaluates whether women carrying BRCA mutations (BRCAm) have decreased ovarian reserve, in terms of Anti-Muellerian Hormone (AMH), compared to women without BRCAm (wild-type). Material and methods: Systematic searches of PubMed, Medline, Scopus, Embase, Science Direct and the Cochrane Library from inception until July 2020 were conducted. All studies comparing AMH level in fertile age women, with and without BRCA pathogenic variants were considered. Sub-analyses were performed according to age, presence of breast cancer, and type of mutation. Results: Among 64 studies, 10 series were included. For the entire cohort, a trend of reduced AMH level were found between BRCAm carriers and women without pathogenic variants. BRCAm carriers aged 41-years or younger had lower AMH levels compared to 41-years or younger wild type women (OR: 0.73 [95%CI-1.12;-0.35]; p = 0.0002). This finding was confirmed for BRCA1m carriers (OR: 1 [95%CI-1.96;-0.05]; p = 0.004) whereas no difference was observed between BRCA2m carriers and wild type women. The same analysis on breast cancer patients with and without BRCAm achieved the same results. Conclusion: Young BRCA1m carriers seem to have lower AMH level compared with wild type women and therefore a potential decreased ovarian reserve.http://www.sciencedirect.com/science/article/pii/S0960977621004628AMHBreast cancerOvarian reserveBRCA1mBRCA2mBRCA pathogenic variants |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Maria Luisa Gasparri Rosa Di Micco Veronica Zuber Katayoun Taghavi Giampaolo Bianchini Serena Bellaminutti Francesco Meani Rossella Graffeo Massimo Candiani Michael D. Mueller Andrea Papadia Oreste D. Gentilini |
spellingShingle |
Maria Luisa Gasparri Rosa Di Micco Veronica Zuber Katayoun Taghavi Giampaolo Bianchini Serena Bellaminutti Francesco Meani Rossella Graffeo Massimo Candiani Michael D. Mueller Andrea Papadia Oreste D. Gentilini Ovarian reserve of women with and without BRCA pathogenic variants: A systematic review and meta-analysis Breast AMH Breast cancer Ovarian reserve BRCA1m BRCA2m BRCA pathogenic variants |
author_facet |
Maria Luisa Gasparri Rosa Di Micco Veronica Zuber Katayoun Taghavi Giampaolo Bianchini Serena Bellaminutti Francesco Meani Rossella Graffeo Massimo Candiani Michael D. Mueller Andrea Papadia Oreste D. Gentilini |
author_sort |
Maria Luisa Gasparri |
title |
Ovarian reserve of women with and without BRCA pathogenic variants: A systematic review and meta-analysis |
title_short |
Ovarian reserve of women with and without BRCA pathogenic variants: A systematic review and meta-analysis |
title_full |
Ovarian reserve of women with and without BRCA pathogenic variants: A systematic review and meta-analysis |
title_fullStr |
Ovarian reserve of women with and without BRCA pathogenic variants: A systematic review and meta-analysis |
title_full_unstemmed |
Ovarian reserve of women with and without BRCA pathogenic variants: A systematic review and meta-analysis |
title_sort |
ovarian reserve of women with and without brca pathogenic variants: a systematic review and meta-analysis |
publisher |
Elsevier |
series |
Breast |
issn |
1532-3080 |
publishDate |
2021-12-01 |
description |
Introduction: Preliminary clinical evidence suggests a detrimental effect of pathogenic variants of BRCA1 and 2 genes on fertility outcome. This meta-analysis evaluates whether women carrying BRCA mutations (BRCAm) have decreased ovarian reserve, in terms of Anti-Muellerian Hormone (AMH), compared to women without BRCAm (wild-type). Material and methods: Systematic searches of PubMed, Medline, Scopus, Embase, Science Direct and the Cochrane Library from inception until July 2020 were conducted. All studies comparing AMH level in fertile age women, with and without BRCA pathogenic variants were considered. Sub-analyses were performed according to age, presence of breast cancer, and type of mutation. Results: Among 64 studies, 10 series were included. For the entire cohort, a trend of reduced AMH level were found between BRCAm carriers and women without pathogenic variants. BRCAm carriers aged 41-years or younger had lower AMH levels compared to 41-years or younger wild type women (OR: 0.73 [95%CI-1.12;-0.35]; p = 0.0002). This finding was confirmed for BRCA1m carriers (OR: 1 [95%CI-1.96;-0.05]; p = 0.004) whereas no difference was observed between BRCA2m carriers and wild type women. The same analysis on breast cancer patients with and without BRCAm achieved the same results. Conclusion: Young BRCA1m carriers seem to have lower AMH level compared with wild type women and therefore a potential decreased ovarian reserve. |
topic |
AMH Breast cancer Ovarian reserve BRCA1m BRCA2m BRCA pathogenic variants |
url |
http://www.sciencedirect.com/science/article/pii/S0960977621004628 |
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