Shoc2/Sur8 protein regulates neurite outgrowth.

Shoc2/Sur8 protein regulates neurite outgrowth.

The Shoc2 protein has been implicated in the positive regulation of the Ras-ERK pathway by increasing the functional binding interaction between Ras and Raf, leading to increased ERK activity. Here we found that Shoc2 overexpression induced sustained ERK phosphorylation, notably in the case of EGF s...

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Bibliographic Details
Main Authors: Gonzalo Leon, Lucia Sanchez-Ruiloba, Andrea Perez-Rodriguez, Teresa Gragera, Natalia Martinez, Silvia Hernandez, Berta Anta, Olga Calero, Carlota A Garcia-Dominguez, Lara M Dura, Daniel Peña-Jimenez, Judit Castro, Natasha Zarich, Pilar Sanchez-Gomez, Miguel Calero, Teresa Iglesias, Jose L Oliva, Jose M Rojas
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4267731?pdf=render

Internet

http://europepmc.org/articles/PMC4267731?pdf=render

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