NS Segment of a 1918 Influenza A Virus-Descendent Enhances Replication of H1N1pdm09 and Virus-Induced Cellular Immune Response in Mammalian and Avian Systems

NS Segment of a 1918 Influenza A Virus-Descendent Enhances Replication of H1N1pdm09 and Virus-Induced Cellular Immune Response in Mammalian and Avian Systems

The 2009 pandemic influenza A virus (IAV) H1N1 strain (H1N1pdm09) has widely spread and is circulating in humans and swine together with other human and avian IAVs. This fact raises the concern that reassortment between H1N1pdm09 and co-circulating viruses might lead to an increase of H1N1pdm09 path...

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Bibliographic Details
Main Authors: Henning Petersen, Ahmed Mostafa, Mohamed A. Tantawy, Azeem A. Iqbal, Donata Hoffmann, Aravind Tallam, Balachandar Selvakumar, Frank Pessler, Martin Beer, Silke Rautenschlein, Stephan Pleschka
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-03-01
Series:Frontiers in Microbiology
Subjects:
H1N1pdm09
influenza virus
NS segment
reassortment
innate immunity
Online Access:http://journal.frontiersin.org/article/10.3389/fmicb.2018.00526/full

Internet

http://journal.frontiersin.org/article/10.3389/fmicb.2018.00526/full

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