Protective Role of Vitamin B1 in Doxorubicin-Induced Cardiotoxicity in Rats: Focus on Hemodynamic, Redox, and Apoptotic Markers in Heart

Protective Role of Vitamin B1 in Doxorubicin-Induced Cardiotoxicity in Rats: Focus on Hemodynamic, Redox, and Apoptotic Markers in Heart

Up until now, the specific mechanisms involved in doxorubicin (DOX)-induced cardiotoxicity have not been fully elucidated. Since thiamine deficiency is associated with myocardial dysfunction and it may lead to cardiomyopathy, we aimed to investigate whether thiamine (Vitamin B1) treatment provides c...

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Bibliographic Details
Main Authors: Marina Rankovic, Nevena Draginic, Jovana Jeremic, Andjela Milojevic Samanovic, Svetlana Stojkov, Slobodanka Mitrovic, Nevena Jeremic, Tanja Radonjic, Ivan Srejovic, Sergey Bolevich, Andrey Svistunov, Vladimir Jakovljevic, Tamara Nikolic Turnic
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Physiology
Subjects:
doxorubicin
cardiotoxicity
thiamine
left ventricular function
heart oxidative stress
apoptosis
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2021.690619/full

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