Does bronchial hyperresponsiveness predict a diagnosis of cough variant asthma in adults with chronic cough: a cohort study
Abstract Bronchial hyperresponsiveness is a typical, but non-specific feature of cough variant asthma (CVA). This study aimed to determine whether bronchial hyperresponsiveness may be considered as a predictor of CVA in non-smoking adults with chronic cough (CC). The study included 55 patients with...
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doaj-558ddec95d05418d824b3bebfcf463532021-09-26T11:41:26ZengBMCRespiratory Research1465-993X2021-09-012211510.1186/s12931-021-01845-2Does bronchial hyperresponsiveness predict a diagnosis of cough variant asthma in adults with chronic cough: a cohort studyAleksandra Rybka-Fraczek0Marta Dabrowska1Elzbieta M. Grabczak2Katarzyna Bialek-Gosk3Karolina Klimowicz4Olga Truba5Rafal Krenke6Department of Internal Medicine, Pulmonary Diseases and Allergy, Medical University of WarsawDepartment of Internal Medicine, Pulmonary Diseases and Allergy, Medical University of WarsawDepartment of Internal Medicine, Pulmonary Diseases and Allergy, Medical University of WarsawDepartment of Internal Medicine, Pulmonary Diseases and Allergy, Medical University of WarsawDepartment of Internal Medicine, Pulmonary Diseases and Allergy, Medical University of WarsawDepartment of Internal Medicine, Pulmonary Diseases and Allergy, Medical University of WarsawDepartment of Internal Medicine, Pulmonary Diseases and Allergy, Medical University of WarsawAbstract Bronchial hyperresponsiveness is a typical, but non-specific feature of cough variant asthma (CVA). This study aimed to determine whether bronchial hyperresponsiveness may be considered as a predictor of CVA in non-smoking adults with chronic cough (CC). The study included 55 patients with CC and bronchial hyperresponsiveness confirmed in the methacholine provocation test, in whom an anti-asthmatic, gradually intensified treatment was introduced. The diagnosis of CVA was established if the improvement in cough severity and cough-related quality of life in LCQ were noted.The study showed a high positive predictive value of bronchial hyperresponsiveness in this population. Cough severity and cough related quality of life were not related to the severity of bronchial hyperresponsiveness in CVA patients. A poor treatment outcome was related to a low baseline capsaicin threshold and the occurrence of gastroesophageal reflux-related symptoms. In conclusion, bronchial hyperresponsiveness could be considered as a predictor of cough variant asthma in non-smoking adults with CC.https://doi.org/10.1186/s12931-021-01845-2AsthmaBronchial hyperresponsivenessCough |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Aleksandra Rybka-Fraczek Marta Dabrowska Elzbieta M. Grabczak Katarzyna Bialek-Gosk Karolina Klimowicz Olga Truba Rafal Krenke |
spellingShingle |
Aleksandra Rybka-Fraczek Marta Dabrowska Elzbieta M. Grabczak Katarzyna Bialek-Gosk Karolina Klimowicz Olga Truba Rafal Krenke Does bronchial hyperresponsiveness predict a diagnosis of cough variant asthma in adults with chronic cough: a cohort study Respiratory Research Asthma Bronchial hyperresponsiveness Cough |
author_facet |
Aleksandra Rybka-Fraczek Marta Dabrowska Elzbieta M. Grabczak Katarzyna Bialek-Gosk Karolina Klimowicz Olga Truba Rafal Krenke |
author_sort |
Aleksandra Rybka-Fraczek |
title |
Does bronchial hyperresponsiveness predict a diagnosis of cough variant asthma in adults with chronic cough: a cohort study |
title_short |
Does bronchial hyperresponsiveness predict a diagnosis of cough variant asthma in adults with chronic cough: a cohort study |
title_full |
Does bronchial hyperresponsiveness predict a diagnosis of cough variant asthma in adults with chronic cough: a cohort study |
title_fullStr |
Does bronchial hyperresponsiveness predict a diagnosis of cough variant asthma in adults with chronic cough: a cohort study |
title_full_unstemmed |
Does bronchial hyperresponsiveness predict a diagnosis of cough variant asthma in adults with chronic cough: a cohort study |
title_sort |
does bronchial hyperresponsiveness predict a diagnosis of cough variant asthma in adults with chronic cough: a cohort study |
publisher |
BMC |
series |
Respiratory Research |
issn |
1465-993X |
publishDate |
2021-09-01 |
description |
Abstract Bronchial hyperresponsiveness is a typical, but non-specific feature of cough variant asthma (CVA). This study aimed to determine whether bronchial hyperresponsiveness may be considered as a predictor of CVA in non-smoking adults with chronic cough (CC). The study included 55 patients with CC and bronchial hyperresponsiveness confirmed in the methacholine provocation test, in whom an anti-asthmatic, gradually intensified treatment was introduced. The diagnosis of CVA was established if the improvement in cough severity and cough-related quality of life in LCQ were noted.The study showed a high positive predictive value of bronchial hyperresponsiveness in this population. Cough severity and cough related quality of life were not related to the severity of bronchial hyperresponsiveness in CVA patients. A poor treatment outcome was related to a low baseline capsaicin threshold and the occurrence of gastroesophageal reflux-related symptoms. In conclusion, bronchial hyperresponsiveness could be considered as a predictor of cough variant asthma in non-smoking adults with CC. |
topic |
Asthma Bronchial hyperresponsiveness Cough |
url |
https://doi.org/10.1186/s12931-021-01845-2 |
work_keys_str_mv |
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