Three-dimensional cultured mesenchymal stem cells enhance repair of ischemic stroke through inhibition of microglia

Three-dimensional cultured mesenchymal stem cells enhance repair of ischemic stroke through inhibition of microglia

Abstract Background We show previously that three-dimensional (3D) spheroid cultured mesenchymal stem cells (MSCs) exhibit reduced cell size thus devoid of lung entrapment following intravenous (IV) infusion. In this study, we determined the therapeutic effect of 3D-cultured MSCs on ischemic stroke...

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Bibliographic Details
Main Authors: Yuejiao Li, Yankai Dong, Ye Ran, Yanan Zhang, Boyao Wu, Jundong Xie, Yanpei Cao, Miaohua Mo, Sen Li, Hao Deng, Wenbo Hao, Shengyuan Yu, Yaojiong Wu
Format: Article
Language:English
Published: BMC 2021-06-01
Series:Stem Cell Research & Therapy
Subjects:
Mesenchymal stem cells
Ischemic stroke
Microglia
Mincle
Neuroinflammation
Online Access:https://doi.org/10.1186/s13287-021-02416-4

Internet

https://doi.org/10.1186/s13287-021-02416-4

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