Neurodegenerative Disease: What Potential Therapeutic Role of Acid-Sensing Ion Channels?
Acidic pH shift occurs in many physiological neuronal activities such as synaptic transmission and synaptic plasticity but also represents a characteristic feature of many pathological conditions including inflammation and ischemia. Neuroinflammation is a complex process that occurs in various neuro...
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Frontiers Media S.A.
2021-10-01
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Online Access: | https://www.frontiersin.org/articles/10.3389/fncel.2021.730641/full |
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doaj-55e6824df7e44236b886f0dab668df7a2021-10-08T04:58:18ZengFrontiers Media S.A.Frontiers in Cellular Neuroscience1662-51022021-10-011510.3389/fncel.2021.730641730641Neurodegenerative Disease: What Potential Therapeutic Role of Acid-Sensing Ion Channels?Dalila Mango0Dalila Mango1Robert Nisticò2Robert Nisticò3Laboratory of Pharmacology of Synaptic Plasticity, European Brain Research Institute, Rome, ItalySchool of Pharmacy, University of Rome “Tor Vergata”, Rome, ItalyLaboratory of Pharmacology of Synaptic Plasticity, European Brain Research Institute, Rome, ItalySchool of Pharmacy, University of Rome “Tor Vergata”, Rome, ItalyAcidic pH shift occurs in many physiological neuronal activities such as synaptic transmission and synaptic plasticity but also represents a characteristic feature of many pathological conditions including inflammation and ischemia. Neuroinflammation is a complex process that occurs in various neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease, multiple sclerosis, and Huntington’s disease. Acid-sensing ion channels (ASICs) represent a widely expressed pH sensor in the brain that play a key role in neuroinflammation. On this basis, acid-sensing ion channel blockers are able to exert neuroprotective effects in different neurodegenerative diseases. In this review, we discuss the multifaceted roles of ASICs in brain physiology and pathology and highlight ASIC1a as a potential pharmacological target in neurodegenerative diseases.https://www.frontiersin.org/articles/10.3389/fncel.2021.730641/fullASIC1aneurodegenerative diseaseneuroinflammationpH shiftacidosis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Dalila Mango Dalila Mango Robert Nisticò Robert Nisticò |
spellingShingle |
Dalila Mango Dalila Mango Robert Nisticò Robert Nisticò Neurodegenerative Disease: What Potential Therapeutic Role of Acid-Sensing Ion Channels? Frontiers in Cellular Neuroscience ASIC1a neurodegenerative disease neuroinflammation pH shift acidosis |
author_facet |
Dalila Mango Dalila Mango Robert Nisticò Robert Nisticò |
author_sort |
Dalila Mango |
title |
Neurodegenerative Disease: What Potential Therapeutic Role of Acid-Sensing Ion Channels? |
title_short |
Neurodegenerative Disease: What Potential Therapeutic Role of Acid-Sensing Ion Channels? |
title_full |
Neurodegenerative Disease: What Potential Therapeutic Role of Acid-Sensing Ion Channels? |
title_fullStr |
Neurodegenerative Disease: What Potential Therapeutic Role of Acid-Sensing Ion Channels? |
title_full_unstemmed |
Neurodegenerative Disease: What Potential Therapeutic Role of Acid-Sensing Ion Channels? |
title_sort |
neurodegenerative disease: what potential therapeutic role of acid-sensing ion channels? |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Cellular Neuroscience |
issn |
1662-5102 |
publishDate |
2021-10-01 |
description |
Acidic pH shift occurs in many physiological neuronal activities such as synaptic transmission and synaptic plasticity but also represents a characteristic feature of many pathological conditions including inflammation and ischemia. Neuroinflammation is a complex process that occurs in various neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease, multiple sclerosis, and Huntington’s disease. Acid-sensing ion channels (ASICs) represent a widely expressed pH sensor in the brain that play a key role in neuroinflammation. On this basis, acid-sensing ion channel blockers are able to exert neuroprotective effects in different neurodegenerative diseases. In this review, we discuss the multifaceted roles of ASICs in brain physiology and pathology and highlight ASIC1a as a potential pharmacological target in neurodegenerative diseases. |
topic |
ASIC1a neurodegenerative disease neuroinflammation pH shift acidosis |
url |
https://www.frontiersin.org/articles/10.3389/fncel.2021.730641/full |
work_keys_str_mv |
AT dalilamango neurodegenerativediseasewhatpotentialtherapeuticroleofacidsensingionchannels AT dalilamango neurodegenerativediseasewhatpotentialtherapeuticroleofacidsensingionchannels AT robertnistico neurodegenerativediseasewhatpotentialtherapeuticroleofacidsensingionchannels AT robertnistico neurodegenerativediseasewhatpotentialtherapeuticroleofacidsensingionchannels |
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1716838730843553792 |