From hype to reality: data science enabling personalized medicine
Abstract Background Personalized, precision, P4, or stratified medicine is understood as a medical approach in which patients are stratified based on their disease subtype, risk, prognosis, or treatment response using specialized diagnostic tests. The key idea is to base medical decisions on individ...
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doaj-55faf984462542e699767e229ee03c8e2020-11-25T02:52:07ZengBMCBMC Medicine1741-70152018-08-0116111510.1186/s12916-018-1122-7From hype to reality: data science enabling personalized medicineHolger Fröhlich0Rudi Balling1Niko Beerenwinkel2Oliver Kohlbacher3Santosh Kumar4Thomas Lengauer5Marloes H. Maathuis6Yves Moreau7Susan A. Murphy8Teresa M. Przytycka9Michael Rebhan10Hannes Röst11Andreas Schuppert12Matthias Schwab13Rainer Spang14Daniel Stekhoven15Jimeng Sun16Andreas Weber17Daniel Ziemek18Blaz Zupan19UCB Biosciences GmbHUniversity of LuxembourgDepartment of Biosciences and Engineering, ETH ZurichUniversity of Tübingen, WSI/ZBITDepartment of Computer Science, University of MemphisMax-Planck-Institute for InformaticsETH Zurich, Seminar für StatistikUniversity of Leuven, ESATHarvard UniversityNational Center of Biotechnology Information, National Institute of HealthNovartis Institutes for Biomedical ResearchDonnelly Centre for Cellular and Biomolecular Research, University of TorontoRWTH Aachen, Joint Research Center for Computational BiomedicineDr. Margarete Fischer-Bosch Institute of Clinical PharmacologyUniversity of Regensburg, Institute of Functional GenomicsETH Zurich, NEXUS Personalized Health Technol.Georgia Tech UniversityInstitute for Computer Science, University of BonnPfizer, Worldwide Research and DevelopmentFaculty of Computer and Information Science, University of LjubljanaAbstract Background Personalized, precision, P4, or stratified medicine is understood as a medical approach in which patients are stratified based on their disease subtype, risk, prognosis, or treatment response using specialized diagnostic tests. The key idea is to base medical decisions on individual patient characteristics, including molecular and behavioral biomarkers, rather than on population averages. Personalized medicine is deeply connected to and dependent on data science, specifically machine learning (often named Artificial Intelligence in the mainstream media). While during recent years there has been a lot of enthusiasm about the potential of ‘big data’ and machine learning-based solutions, there exist only few examples that impact current clinical practice. The lack of impact on clinical practice can largely be attributed to insufficient performance of predictive models, difficulties to interpret complex model predictions, and lack of validation via prospective clinical trials that demonstrate a clear benefit compared to the standard of care. In this paper, we review the potential of state-of-the-art data science approaches for personalized medicine, discuss open challenges, and highlight directions that may help to overcome them in the future. Conclusions There is a need for an interdisciplinary effort, including data scientists, physicians, patient advocates, regulatory agencies, and health insurance organizations. Partially unrealistic expectations and concerns about data science-based solutions need to be better managed. In parallel, computational methods must advance more to provide direct benefit to clinical practice.http://link.springer.com/article/10.1186/s12916-018-1122-7Personalized medicinePrecision medicineStratified medicineP4 medicineMachine learningArtificial intelligence |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Holger Fröhlich Rudi Balling Niko Beerenwinkel Oliver Kohlbacher Santosh Kumar Thomas Lengauer Marloes H. Maathuis Yves Moreau Susan A. Murphy Teresa M. Przytycka Michael Rebhan Hannes Röst Andreas Schuppert Matthias Schwab Rainer Spang Daniel Stekhoven Jimeng Sun Andreas Weber Daniel Ziemek Blaz Zupan |
spellingShingle |
Holger Fröhlich Rudi Balling Niko Beerenwinkel Oliver Kohlbacher Santosh Kumar Thomas Lengauer Marloes H. Maathuis Yves Moreau Susan A. Murphy Teresa M. Przytycka Michael Rebhan Hannes Röst Andreas Schuppert Matthias Schwab Rainer Spang Daniel Stekhoven Jimeng Sun Andreas Weber Daniel Ziemek Blaz Zupan From hype to reality: data science enabling personalized medicine BMC Medicine Personalized medicine Precision medicine Stratified medicine P4 medicine Machine learning Artificial intelligence |
author_facet |
Holger Fröhlich Rudi Balling Niko Beerenwinkel Oliver Kohlbacher Santosh Kumar Thomas Lengauer Marloes H. Maathuis Yves Moreau Susan A. Murphy Teresa M. Przytycka Michael Rebhan Hannes Röst Andreas Schuppert Matthias Schwab Rainer Spang Daniel Stekhoven Jimeng Sun Andreas Weber Daniel Ziemek Blaz Zupan |
author_sort |
Holger Fröhlich |
title |
From hype to reality: data science enabling personalized medicine |
title_short |
From hype to reality: data science enabling personalized medicine |
title_full |
From hype to reality: data science enabling personalized medicine |
title_fullStr |
From hype to reality: data science enabling personalized medicine |
title_full_unstemmed |
From hype to reality: data science enabling personalized medicine |
title_sort |
from hype to reality: data science enabling personalized medicine |
publisher |
BMC |
series |
BMC Medicine |
issn |
1741-7015 |
publishDate |
2018-08-01 |
description |
Abstract Background Personalized, precision, P4, or stratified medicine is understood as a medical approach in which patients are stratified based on their disease subtype, risk, prognosis, or treatment response using specialized diagnostic tests. The key idea is to base medical decisions on individual patient characteristics, including molecular and behavioral biomarkers, rather than on population averages. Personalized medicine is deeply connected to and dependent on data science, specifically machine learning (often named Artificial Intelligence in the mainstream media). While during recent years there has been a lot of enthusiasm about the potential of ‘big data’ and machine learning-based solutions, there exist only few examples that impact current clinical practice. The lack of impact on clinical practice can largely be attributed to insufficient performance of predictive models, difficulties to interpret complex model predictions, and lack of validation via prospective clinical trials that demonstrate a clear benefit compared to the standard of care. In this paper, we review the potential of state-of-the-art data science approaches for personalized medicine, discuss open challenges, and highlight directions that may help to overcome them in the future. Conclusions There is a need for an interdisciplinary effort, including data scientists, physicians, patient advocates, regulatory agencies, and health insurance organizations. Partially unrealistic expectations and concerns about data science-based solutions need to be better managed. In parallel, computational methods must advance more to provide direct benefit to clinical practice. |
topic |
Personalized medicine Precision medicine Stratified medicine P4 medicine Machine learning Artificial intelligence |
url |
http://link.springer.com/article/10.1186/s12916-018-1122-7 |
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