Cyclical DNA Methylation and Histone Changes Are Induced by LPS to Activate COX-2 in Human Intestinal Epithelial Cells.

Bacterial lipopolysaccharide (LPS) induces release of inflammatory mediators both in immune and epithelial cells. We investigated whether changes of epigenetic marks, including selected histone modification and DNA methylation, may drive or accompany the activation of COX-2 gene in HT-29 human intes...

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Main Authors: Tiziana Angrisano, Raffaela Pero, Mariarita Brancaccio, Lorena Coretti, Ermanno Florio, Antonio Pezone, Viola Calabrò, Geppino Falco, Simona Keller, Francesca Lembo, Vittorio Enrico Avvedimento, Lorenzo Chiariotti
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4890762?pdf=render