Topical Administration of Bosentan Prevents Retinal Neurodegeneration in Experimental Diabetes

Topical Administration of Bosentan Prevents Retinal Neurodegeneration in Experimental Diabetes

Experimental evidence suggests that endothelin 1 (ET-1) is involved in the development of retinal microvascular abnormalities induced by diabetes. The effects of ET-1 are mediated by endothelin A- and B-receptors (ETA and ETB). Endothelin B-receptors activation mediates retinal neurodegeneration but...

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Bibliographic Details
Main Authors: Patricia Bogdanov, Olga Simó-Servat, Joel Sampedro, Cristina Solà-Adell, Marta Garcia-Ramírez, Hugo Ramos, Marta Guerrero, Josep Maria Suñé-Negre, Josep Ramon Ticó, Bruno Montoro, Vicente Durán, Luís Arias, Cristina Hernández, Rafael Simó
Format: Article
Language:English
Published: MDPI AG 2018-11-01
Series:International Journal of Molecular Sciences
Subjects:
diabetic retinopathy
retinal neurodegeneration
endothelin-1
bosentan
db/db mouse
Online Access:https://www.mdpi.com/1422-0067/19/11/3578

Internet

https://www.mdpi.com/1422-0067/19/11/3578

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