Imbalance of Th17/Treg in Different Subtypes of Autoimmune Thyroid Diseases
Aims: To clarify the imbalance of Th17/Treg in different subtypes of autoimmune thyroid diseases (AITDs) including Graves' disease(GD), Hashimoto's thyroiditis(HT) and Graves' ophthalmopathy (GO). Methods: 47 patients with AITD (including 16 GD, 15 HT, and 16 GO) and 12 healthy contro...
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Cell Physiol Biochem Press GmbH & Co KG
2016-11-01
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doaj-563d682ec4bb4d3db386cdf03a4bd12a2020-11-25T00:59:32ZengCell Physiol Biochem Press GmbH & Co KGCellular Physiology and Biochemistry1015-89871421-97782016-11-01401-224525210.1159/000452541452541Imbalance of Th17/Treg in Different Subtypes of Autoimmune Thyroid DiseasesCui LiJianghong YuanYuan-feng ZhuXiang-ju YangQiong WangJian XuShuang-tao HeJin-an ZhangAims: To clarify the imbalance of Th17/Treg in different subtypes of autoimmune thyroid diseases (AITDs) including Graves' disease(GD), Hashimoto's thyroiditis(HT) and Graves' ophthalmopathy (GO). Methods: 47 patients with AITD (including 16 GD, 15 HT, and 16 GO) and 12 healthy controls were enrolled in this study. The percentages of Th17 and Treg cells, the ratio of Th17/Treg, as well as their related transcription factors RORγt and Foxp3 mRNA in peripheral blood mononuclear cells (PBMCs) were measured by flow cytometry and real-time quantitative PCR Results: Compared with those in control group, the percentage of CD4+IL-17+T cell(Th17) and the mRNA expression of its transcription factor RORγt were higher in PBMCs of AITDs (P+Foxp3+T (Treg) cells and its transcription factor Foxp3 mRNA were significantly decreased in PBMCs of GD (PConclusion: Increased Th17 lymphocytes may play a more important role in the pathogenesis of HT and GO while decreased Treg may be greatly involved in GD.http://www.karger.com/Article/FullText/452541Graves’ disease (GD)Hashimoto’s thyroiditis (HT)Graves’ ophthalmopathy (GO)T helper 17 cell (Th17)Regulatory T cell (Treg) |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Cui Li Jianghong Yuan Yuan-feng Zhu Xiang-ju Yang Qiong Wang Jian Xu Shuang-tao He Jin-an Zhang |
spellingShingle |
Cui Li Jianghong Yuan Yuan-feng Zhu Xiang-ju Yang Qiong Wang Jian Xu Shuang-tao He Jin-an Zhang Imbalance of Th17/Treg in Different Subtypes of Autoimmune Thyroid Diseases Cellular Physiology and Biochemistry Graves’ disease (GD) Hashimoto’s thyroiditis (HT) Graves’ ophthalmopathy (GO) T helper 17 cell (Th17) Regulatory T cell (Treg) |
author_facet |
Cui Li Jianghong Yuan Yuan-feng Zhu Xiang-ju Yang Qiong Wang Jian Xu Shuang-tao He Jin-an Zhang |
author_sort |
Cui Li |
title |
Imbalance of Th17/Treg in Different Subtypes of Autoimmune Thyroid Diseases |
title_short |
Imbalance of Th17/Treg in Different Subtypes of Autoimmune Thyroid Diseases |
title_full |
Imbalance of Th17/Treg in Different Subtypes of Autoimmune Thyroid Diseases |
title_fullStr |
Imbalance of Th17/Treg in Different Subtypes of Autoimmune Thyroid Diseases |
title_full_unstemmed |
Imbalance of Th17/Treg in Different Subtypes of Autoimmune Thyroid Diseases |
title_sort |
imbalance of th17/treg in different subtypes of autoimmune thyroid diseases |
publisher |
Cell Physiol Biochem Press GmbH & Co KG |
series |
Cellular Physiology and Biochemistry |
issn |
1015-8987 1421-9778 |
publishDate |
2016-11-01 |
description |
Aims: To clarify the imbalance of Th17/Treg in different subtypes of autoimmune thyroid diseases (AITDs) including Graves' disease(GD), Hashimoto's thyroiditis(HT) and Graves' ophthalmopathy (GO). Methods: 47 patients with AITD (including 16 GD, 15 HT, and 16 GO) and 12 healthy controls were enrolled in this study. The percentages of Th17 and Treg cells, the ratio of Th17/Treg, as well as their related transcription factors RORγt and Foxp3 mRNA in peripheral blood mononuclear cells (PBMCs) were measured by flow cytometry and real-time quantitative PCR Results: Compared with those in control group, the percentage of CD4+IL-17+T cell(Th17) and the mRNA expression of its transcription factor RORγt were higher in PBMCs of AITDs (P+Foxp3+T (Treg) cells and its transcription factor Foxp3 mRNA were significantly decreased in PBMCs of GD (PConclusion: Increased Th17 lymphocytes may play a more important role in the pathogenesis of HT and GO while decreased Treg may be greatly involved in GD. |
topic |
Graves’ disease (GD) Hashimoto’s thyroiditis (HT) Graves’ ophthalmopathy (GO) T helper 17 cell (Th17) Regulatory T cell (Treg) |
url |
http://www.karger.com/Article/FullText/452541 |
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