Imbalance of Th17/Treg in Different Subtypes of Autoimmune Thyroid Diseases

Aims: To clarify the imbalance of Th17/Treg in different subtypes of autoimmune thyroid diseases (AITDs) including Graves' disease(GD), Hashimoto's thyroiditis(HT) and Graves' ophthalmopathy (GO). Methods: 47 patients with AITD (including 16 GD, 15 HT, and 16 GO) and 12 healthy contro...

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Main Authors: Cui Li, Jianghong Yuan, Yuan-feng Zhu, Xiang-ju Yang, Qiong Wang, Jian Xu, Shuang-tao He, Jin-an Zhang
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2016-11-01
Series:Cellular Physiology and Biochemistry
Subjects:
Online Access:http://www.karger.com/Article/FullText/452541
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spelling doaj-563d682ec4bb4d3db386cdf03a4bd12a2020-11-25T00:59:32ZengCell Physiol Biochem Press GmbH & Co KGCellular Physiology and Biochemistry1015-89871421-97782016-11-01401-224525210.1159/000452541452541Imbalance of Th17/Treg in Different Subtypes of Autoimmune Thyroid DiseasesCui LiJianghong YuanYuan-feng ZhuXiang-ju YangQiong WangJian XuShuang-tao HeJin-an ZhangAims: To clarify the imbalance of Th17/Treg in different subtypes of autoimmune thyroid diseases (AITDs) including Graves' disease(GD), Hashimoto's thyroiditis(HT) and Graves' ophthalmopathy (GO). Methods: 47 patients with AITD (including 16 GD, 15 HT, and 16 GO) and 12 healthy controls were enrolled in this study. The percentages of Th17 and Treg cells, the ratio of Th17/Treg, as well as their related transcription factors RORγt and Foxp3 mRNA in peripheral blood mononuclear cells (PBMCs) were measured by flow cytometry and real-time quantitative PCR Results: Compared with those in control group, the percentage of CD4+IL-17+T cell(Th17) and the mRNA expression of its transcription factor RORγt were higher in PBMCs of AITDs (P+Foxp3+T (Treg) cells and its transcription factor Foxp3 mRNA were significantly decreased in PBMCs of GD (PConclusion: Increased Th17 lymphocytes may play a more important role in the pathogenesis of HT and GO while decreased Treg may be greatly involved in GD.http://www.karger.com/Article/FullText/452541Graves’ disease (GD)Hashimoto’s thyroiditis (HT)Graves’ ophthalmopathy (GO)T helper 17 cell (Th17)Regulatory T cell (Treg)
collection DOAJ
language English
format Article
sources DOAJ
author Cui Li
Jianghong Yuan
Yuan-feng Zhu
Xiang-ju Yang
Qiong Wang
Jian Xu
Shuang-tao He
Jin-an Zhang
spellingShingle Cui Li
Jianghong Yuan
Yuan-feng Zhu
Xiang-ju Yang
Qiong Wang
Jian Xu
Shuang-tao He
Jin-an Zhang
Imbalance of Th17/Treg in Different Subtypes of Autoimmune Thyroid Diseases
Cellular Physiology and Biochemistry
Graves’ disease (GD)
Hashimoto’s thyroiditis (HT)
Graves’ ophthalmopathy (GO)
T helper 17 cell (Th17)
Regulatory T cell (Treg)
author_facet Cui Li
Jianghong Yuan
Yuan-feng Zhu
Xiang-ju Yang
Qiong Wang
Jian Xu
Shuang-tao He
Jin-an Zhang
author_sort Cui Li
title Imbalance of Th17/Treg in Different Subtypes of Autoimmune Thyroid Diseases
title_short Imbalance of Th17/Treg in Different Subtypes of Autoimmune Thyroid Diseases
title_full Imbalance of Th17/Treg in Different Subtypes of Autoimmune Thyroid Diseases
title_fullStr Imbalance of Th17/Treg in Different Subtypes of Autoimmune Thyroid Diseases
title_full_unstemmed Imbalance of Th17/Treg in Different Subtypes of Autoimmune Thyroid Diseases
title_sort imbalance of th17/treg in different subtypes of autoimmune thyroid diseases
publisher Cell Physiol Biochem Press GmbH & Co KG
series Cellular Physiology and Biochemistry
issn 1015-8987
1421-9778
publishDate 2016-11-01
description Aims: To clarify the imbalance of Th17/Treg in different subtypes of autoimmune thyroid diseases (AITDs) including Graves' disease(GD), Hashimoto's thyroiditis(HT) and Graves' ophthalmopathy (GO). Methods: 47 patients with AITD (including 16 GD, 15 HT, and 16 GO) and 12 healthy controls were enrolled in this study. The percentages of Th17 and Treg cells, the ratio of Th17/Treg, as well as their related transcription factors RORγt and Foxp3 mRNA in peripheral blood mononuclear cells (PBMCs) were measured by flow cytometry and real-time quantitative PCR Results: Compared with those in control group, the percentage of CD4+IL-17+T cell(Th17) and the mRNA expression of its transcription factor RORγt were higher in PBMCs of AITDs (P+Foxp3+T (Treg) cells and its transcription factor Foxp3 mRNA were significantly decreased in PBMCs of GD (PConclusion: Increased Th17 lymphocytes may play a more important role in the pathogenesis of HT and GO while decreased Treg may be greatly involved in GD.
topic Graves’ disease (GD)
Hashimoto’s thyroiditis (HT)
Graves’ ophthalmopathy (GO)
T helper 17 cell (Th17)
Regulatory T cell (Treg)
url http://www.karger.com/Article/FullText/452541
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