Elastin homeostasis is altered with pelvic organ prolapse in cultures of vaginal cells from a lysyl oxidase‐like 1 knockout mouse model

Elastin homeostasis is altered with pelvic organ prolapse in cultures of vaginal cells from a lysyl oxidase‐like 1 knockout mouse model

Abstract Pelvic organ prolapse (POP) decreases quality of life for many women, but its pathophysiology is poorly understood. We have previously shown that Lysyl oxidase‐like 1 knockout (Loxl1 KO) mice reliably prolapse with age and increased parity, similar to women. Both this model and clinical stu...

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Bibliographic Details
Main Authors: Slater A. Jameson, Ganesh Swaminathan, Shataakshi Dahal, Bruna Couri, Mei Kuang, Anna Rietsch, Robert S. Butler, Anand Ramamurthi, Margot S. Damaser
Format: Article
Language:English
Published: Wiley 2020-06-01
Series:Physiological Reports
Subjects:
cross‐link
extracellular matrix
matrix metalloproteinase
tissue inhibitors of matrix metalloproteinase
tropoelastin
Online Access:https://doi.org/10.14814/phy2.14436

Internet

https://doi.org/10.14814/phy2.14436

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