Allele frequency misspecification: effect on power and Type I error of model-dependent linkage analysis of quantitative traits under random ascertainment

<p>Abstract</p> <p>Background</p> <p>Studies of model-based linkage analysis show that trait or marker model misspecification leads to decreasing power or increasing Type I error rate. An increase in Type I error rate is seen when marker related parameters (e.g., allele...

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Bibliographic Details
Main Authors: Wilson Alexander F, Atwood Larry D, Sorant Alexa JM, Mandal Diptasri M, Bailey-Wilson Joan E
Format: Article
Language:English
Published: BMC 2006-04-01
Series:BMC Genetics
Online Access:http://www.biomedcentral.com/1471-2156/7/21