Higher-Order Looping and Nuclear Organization of Tcra Facilitate Targeted RAG Cleavage and Regulated Rearrangement in Recombination Centers

Higher-Order Looping and Nuclear Organization of Tcra Facilitate Targeted RAG Cleavage and Regulated Rearrangement in Recombination Centers

V(D)J recombination is essential for generating a diverse array of B and T cell receptors that can recognize and combat foreign antigens. As with any recombination event, tight control is essential to prevent the occurrence of genetic anomalies that drive cellular transformation. One important aspe...

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Bibliographic Details
Main Authors: Julie Chaumeil, Mariann Micsinai, Panagiotis Ntziachristos, Ludovic Deriano, Joy M.-H. Wang, Yanhong Ji, Elphege P. Nora, Matthew J. Rodesch, Jeffrey A. Jeddeloh, Iannis Aifantis, Yuval Kluger, David G. Schatz, Jane A. Skok
Format: Article
Language:English
Published: Elsevier 2013-02-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124713000314

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http://www.sciencedirect.com/science/article/pii/S2211124713000314

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