Nanog maintains stemness of Lkb1‐deficient lung adenocarcinoma and prevents gastric differentiation

Abstract Growing evidence supports that LKB1‐deficient KRAS‐driven lung tumors represent a unique therapeutic challenge, displaying strong cancer plasticity that promotes lineage conversion and drug resistance. Here we find that murine lung tumors from the KrasLSL‐G12D/+; Lkb1flox/flox (KL) model sh...

Full description

Bibliographic Details
Main Authors: Xinyuan Tong, Yueqing Chen, Xinsheng Zhu, Yi Ye, Yun Xue, Rui Wang, Yijun Gao, Wenjing Zhang, Weiqiang Gao, Lei Xiao, Haiquan Chen, Peng Zhang, Hongbin Ji
Format: Article
Published: Wiley 2021-03-01
Series:EMBO Molecular Medicine
Online Access: