Iron Metabolism and Brain Development in Premature Infants

Iron is important for a remarkable array of essential functions during brain development, and it needs to be provided in adequate amounts, especially to preterm infants. In this review article, we provide an overview of iron metabolism and homeostasis at the cellular level, as well as its regulation...

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Main Authors: Yafeng Wang, Yanan Wu, Tao Li, Xiaoyang Wang, Changlian Zhu
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-04-01
Series:Frontiers in Physiology
Subjects:
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2019.00463/full
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spelling doaj-57d28f388f2a411992f848839db54a5f2020-11-25T01:56:00ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2019-04-011010.3389/fphys.2019.00463428141Iron Metabolism and Brain Development in Premature InfantsYafeng Wang0Yafeng Wang1Yafeng Wang2Yanan Wu3Tao Li4Tao Li5Tao Li6Xiaoyang Wang7Xiaoyang Wang8Changlian Zhu9Changlian Zhu10Department of Neonatology (NICU), Children’s Hospital Affiliated Zhengzhou University, Zhengzhou, ChinaHenan Key Laboratory of Child Brain Injury, Institute of Neuroscience and Third Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaDepartment of Clinical Neuroscience, Center for Brain Repair and Rehabilitation, Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, SwedenHenan Key Laboratory of Child Brain Injury, Institute of Neuroscience and Third Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaDepartment of Neonatology (NICU), Children’s Hospital Affiliated Zhengzhou University, Zhengzhou, ChinaHenan Key Laboratory of Child Brain Injury, Institute of Neuroscience and Third Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaDepartment of Clinical Neuroscience, Center for Brain Repair and Rehabilitation, Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, SwedenHenan Key Laboratory of Child Brain Injury, Institute of Neuroscience and Third Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaDepartment of Physiology, Sahlgrenska Academy, Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, SwedenHenan Key Laboratory of Child Brain Injury, Institute of Neuroscience and Third Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaDepartment of Clinical Neuroscience, Center for Brain Repair and Rehabilitation, Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, SwedenIron is important for a remarkable array of essential functions during brain development, and it needs to be provided in adequate amounts, especially to preterm infants. In this review article, we provide an overview of iron metabolism and homeostasis at the cellular level, as well as its regulation at the mRNA translation level, and we emphasize the importance of iron for brain development in fetal and early life in preterm infants. We also review the risk factors for disrupted iron metabolism that lead to high risk of developing iron deficiency and subsequent adverse effects on neurodevelopment in preterm infants. At the other extreme, iron overload, which is usually caused by excess iron supplementation in iron-replete preterm infants, might negatively impact brain development or even induce brain injury. Maintaining the balance of iron during the fetal and neonatal periods is important, and thus iron status should be monitored routinely and evaluated thoroughly during the neonatal period or before discharge of preterm infants so that iron supplementation can be individualized.https://www.frontiersin.org/article/10.3389/fphys.2019.00463/fullbrain developmentbrain injuryiron metabolismiron homeostasispreterm infants
collection DOAJ
language English
format Article
sources DOAJ
author Yafeng Wang
Yafeng Wang
Yafeng Wang
Yanan Wu
Tao Li
Tao Li
Tao Li
Xiaoyang Wang
Xiaoyang Wang
Changlian Zhu
Changlian Zhu
spellingShingle Yafeng Wang
Yafeng Wang
Yafeng Wang
Yanan Wu
Tao Li
Tao Li
Tao Li
Xiaoyang Wang
Xiaoyang Wang
Changlian Zhu
Changlian Zhu
Iron Metabolism and Brain Development in Premature Infants
Frontiers in Physiology
brain development
brain injury
iron metabolism
iron homeostasis
preterm infants
author_facet Yafeng Wang
Yafeng Wang
Yafeng Wang
Yanan Wu
Tao Li
Tao Li
Tao Li
Xiaoyang Wang
Xiaoyang Wang
Changlian Zhu
Changlian Zhu
author_sort Yafeng Wang
title Iron Metabolism and Brain Development in Premature Infants
title_short Iron Metabolism and Brain Development in Premature Infants
title_full Iron Metabolism and Brain Development in Premature Infants
title_fullStr Iron Metabolism and Brain Development in Premature Infants
title_full_unstemmed Iron Metabolism and Brain Development in Premature Infants
title_sort iron metabolism and brain development in premature infants
publisher Frontiers Media S.A.
series Frontiers in Physiology
issn 1664-042X
publishDate 2019-04-01
description Iron is important for a remarkable array of essential functions during brain development, and it needs to be provided in adequate amounts, especially to preterm infants. In this review article, we provide an overview of iron metabolism and homeostasis at the cellular level, as well as its regulation at the mRNA translation level, and we emphasize the importance of iron for brain development in fetal and early life in preterm infants. We also review the risk factors for disrupted iron metabolism that lead to high risk of developing iron deficiency and subsequent adverse effects on neurodevelopment in preterm infants. At the other extreme, iron overload, which is usually caused by excess iron supplementation in iron-replete preterm infants, might negatively impact brain development or even induce brain injury. Maintaining the balance of iron during the fetal and neonatal periods is important, and thus iron status should be monitored routinely and evaluated thoroughly during the neonatal period or before discharge of preterm infants so that iron supplementation can be individualized.
topic brain development
brain injury
iron metabolism
iron homeostasis
preterm infants
url https://www.frontiersin.org/article/10.3389/fphys.2019.00463/full
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