fMRI reveals neural activity overlap between adult and infant pain

Limited understanding of infant pain has led to its lack of recognition in clinical practice. While the network of brain regions that encode the affective and sensory aspects of adult pain are well described, the brain structures involved in infant nociceptive processing are less well known, meaning...

Full description

Bibliographic Details
Main Authors:	Sezgi Goksan, Caroline Hartley, Faith Emery, Naomi Cockrill, Ravi Poorun, Fiona Moultrie, Richard Rogers, Jon Campbell, Michael Sanders, Eleri Adams, Stuart Clare, Mark Jenkinson, Irene Tracey, Rebeccah Slater
Format:	Article
Language:	English
Published:	eLife Sciences Publications Ltd 2015-04-01
Series:	eLife
Subjects:	pain fMRI infant development
Online Access:	https://elifesciences.org/articles/06356

id	doaj-57ea2825e4fc466c8a8da9edfa47c7ac
record_format	Article
spelling	doaj-57ea2825e4fc466c8a8da9edfa47c7ac2021-05-04T23:45:01ZengeLife Sciences Publications LtdeLife2050-084X2015-04-01410.7554/eLife.06356fMRI reveals neural activity overlap between adult and infant painSezgi Goksan0Caroline Hartley1https://orcid.org/0000-0002-7981-0836Faith Emery2Naomi Cockrill3Ravi Poorun4Fiona Moultrie5Richard Rogers6Jon Campbell7Michael Sanders8Eleri Adams9Stuart Clare10Mark Jenkinson11Irene Tracey12Rebeccah Slater13Oxford Centre for Functional Magnetic Resonance Imaging of the Brain, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United KingdomDepartment of Paediatrics, University of Oxford, Oxford, United KingdomDepartment of Paediatrics, University of Oxford, Oxford, United KingdomDepartment of Paediatrics, University of Oxford, Oxford, United KingdomOxford Centre for Functional Magnetic Resonance Imaging of the Brain, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United KingdomDepartment of Paediatrics, University of Oxford, Oxford, United KingdomOxford Centre for Functional Magnetic Resonance Imaging of the Brain, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United KingdomOxford Centre for Functional Magnetic Resonance Imaging of the Brain, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United KingdomOxford Centre for Functional Magnetic Resonance Imaging of the Brain, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United KingdomDepartment of Paediatrics, University of Oxford, Oxford, United KingdomOxford Centre for Functional Magnetic Resonance Imaging of the Brain, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United KingdomOxford Centre for Functional Magnetic Resonance Imaging of the Brain, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United KingdomOxford Centre for Functional Magnetic Resonance Imaging of the Brain, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United KingdomOxford Centre for Functional Magnetic Resonance Imaging of the Brain, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom; Department of Paediatrics, University of Oxford, Oxford, United KingdomLimited understanding of infant pain has led to its lack of recognition in clinical practice. While the network of brain regions that encode the affective and sensory aspects of adult pain are well described, the brain structures involved in infant nociceptive processing are less well known, meaning little can be inferred about the nature of the infant pain experience. Using fMRI we identified the network of brain regions that are active following acute noxious stimulation in newborn infants, and compared the activity to that observed in adults. Significant infant brain activity was observed in 18 of the 20 active adult brain regions but not in the infant amygdala or orbitofrontal cortex. Brain regions that encode sensory and affective components of pain are active in infants, suggesting that the infant pain experience closely resembles that seen in adults. This highlights the importance of developing effective pain management strategies in this vulnerable population.https://elifesciences.org/articles/06356painfMRIinfantdevelopment
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Sezgi Goksan Caroline Hartley Faith Emery Naomi Cockrill Ravi Poorun Fiona Moultrie Richard Rogers Jon Campbell Michael Sanders Eleri Adams Stuart Clare Mark Jenkinson Irene Tracey Rebeccah Slater
spellingShingle	Sezgi Goksan Caroline Hartley Faith Emery Naomi Cockrill Ravi Poorun Fiona Moultrie Richard Rogers Jon Campbell Michael Sanders Eleri Adams Stuart Clare Mark Jenkinson Irene Tracey Rebeccah Slater fMRI reveals neural activity overlap between adult and infant pain eLife pain fMRI infant development
author_facet	Sezgi Goksan Caroline Hartley Faith Emery Naomi Cockrill Ravi Poorun Fiona Moultrie Richard Rogers Jon Campbell Michael Sanders Eleri Adams Stuart Clare Mark Jenkinson Irene Tracey Rebeccah Slater
author_sort	Sezgi Goksan
title	fMRI reveals neural activity overlap between adult and infant pain
title_short	fMRI reveals neural activity overlap between adult and infant pain
title_full	fMRI reveals neural activity overlap between adult and infant pain
title_fullStr	fMRI reveals neural activity overlap between adult and infant pain
title_full_unstemmed	fMRI reveals neural activity overlap between adult and infant pain
title_sort	fmri reveals neural activity overlap between adult and infant pain
publisher	eLife Sciences Publications Ltd
series	eLife
issn	2050-084X
publishDate	2015-04-01
description	Limited understanding of infant pain has led to its lack of recognition in clinical practice. While the network of brain regions that encode the affective and sensory aspects of adult pain are well described, the brain structures involved in infant nociceptive processing are less well known, meaning little can be inferred about the nature of the infant pain experience. Using fMRI we identified the network of brain regions that are active following acute noxious stimulation in newborn infants, and compared the activity to that observed in adults. Significant infant brain activity was observed in 18 of the 20 active adult brain regions but not in the infant amygdala or orbitofrontal cortex. Brain regions that encode sensory and affective components of pain are active in infants, suggesting that the infant pain experience closely resembles that seen in adults. This highlights the importance of developing effective pain management strategies in this vulnerable population.
topic	pain fMRI infant development
url	https://elifesciences.org/articles/06356
work_keys_str_mv	AT sezgigoksan fmrirevealsneuralactivityoverlapbetweenadultandinfantpain AT carolinehartley fmrirevealsneuralactivityoverlapbetweenadultandinfantpain AT faithemery fmrirevealsneuralactivityoverlapbetweenadultandinfantpain AT naomicockrill fmrirevealsneuralactivityoverlapbetweenadultandinfantpain AT ravipoorun fmrirevealsneuralactivityoverlapbetweenadultandinfantpain AT fionamoultrie fmrirevealsneuralactivityoverlapbetweenadultandinfantpain AT richardrogers fmrirevealsneuralactivityoverlapbetweenadultandinfantpain AT joncampbell fmrirevealsneuralactivityoverlapbetweenadultandinfantpain AT michaelsanders fmrirevealsneuralactivityoverlapbetweenadultandinfantpain AT eleriadams fmrirevealsneuralactivityoverlapbetweenadultandinfantpain AT stuartclare fmrirevealsneuralactivityoverlapbetweenadultandinfantpain AT markjenkinson fmrirevealsneuralactivityoverlapbetweenadultandinfantpain AT irenetracey fmrirevealsneuralactivityoverlapbetweenadultandinfantpain AT rebeccahslater fmrirevealsneuralactivityoverlapbetweenadultandinfantpain
_version_	1721476855375069184

fMRI reveals neural activity overlap between adult and infant pain

Similar Items