Differential transcriptional profiles identify microglial- and macrophage-specific gene markers expressed during virus-induced neuroinflammation

Differential transcriptional profiles identify microglial- and macrophage-specific gene markers expressed during virus-induced neuroinflammation

Abstract Background In the healthy central nervous system (CNS), microglia are found in a homeostatic state and peripheral macrophages are absent from the brain. Microglia play key roles in maintaining CNS homeostasis and acting as first responders to infection and inflammation, and peripheral macro...

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Bibliographic Details
Main Authors: Ana Beatriz DePaula-Silva, Carlos Gorbea, Daniel J. Doty, Jane E. Libbey, John Michael S. Sanchez, Tyler J. Hanak, Demián Cazalla, Robert S. Fujinami
Format: Article
Language:English
Published: BMC 2019-07-01
Series:Journal of Neuroinflammation
Subjects:
Microglia
Macrophages
Cell-specific markers
RNA-Seq
Neuroinflammation
Immune response
Online Access:http://link.springer.com/article/10.1186/s12974-019-1545-x

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http://link.springer.com/article/10.1186/s12974-019-1545-x

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