Vaccination in Patients with Chronic Lymphocytic Leukemia: Current Problems
Relevance. Infections are the most common complication of chronic lymphocytic leukemia (CLL). According to registry studies, infections are the cause of death in 10–20% of patients. The emergence of new therapies for CLL has led to a decrease in mortality due to CLL progression, while mortality from...
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Numikom LLC
2021-07-01
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doaj-581ae14b7528447db1958bdccd3e6ea82021-07-28T13:31:53ZrusNumikom LLCЭпидемиология и вакцинопрофилактика2073-30462619-04942021-07-012039110610.31631/2073-3046-2021-20-3-91-106755Vaccination in Patients with Chronic Lymphocytic Leukemia: Current ProblemsM. I. Kislova0A. A. Petrenko1M. P. Kostinov2E. A. Nikitin3National Research Center for Hematology, Moscow, Russian Federation; Sechenov First Moscow State Medical University (Sechenov University)Botkin City Clinical Hospital; Russian Medical Academy of Continuous Professional EducationSechenov First Moscow State Medical University (Sechenov University); I. Mechnikov Research Institute of Vaccines and SeraBotkin City Clinical Hospital; Russian Medical Academy of Continuous Professional EducationRelevance. Infections are the most common complication of chronic lymphocytic leukemia (CLL). According to registry studies, infections are the cause of death in 10–20% of patients. The emergence of new therapies for CLL has led to a decrease in mortality due to CLL progression, while mortality from infections has remained constant in recent decades.The aim of this literature review is to analyze the effectiveness of vaccine prophylaxis in patients with CLL as well as predictors of vaccine inefficiency according to published data, to explore current guidelines.Conclusions. The mechanisms of immune dysfunction in CLL are complex and associated with both the disease itself and the therapy. Numerous studies have shown that patients with CLL have an inadequate response to most vaccines given routinely in the general population. Vaccination in CLL patients remains a poorly developed topic. Additional clinical trials are needed to improve the effectiveness of vaccination in patients with CLL.https://www.epidemvac.ru/jour/article/view/1294сhronic lymphocytic leukemiasecondary immunodeficiencyvaccinationpneumococcal vaccinationinfluenza vaccinationantibody failure |
collection |
DOAJ |
language |
Russian |
format |
Article |
sources |
DOAJ |
author |
M. I. Kislova A. A. Petrenko M. P. Kostinov E. A. Nikitin |
spellingShingle |
M. I. Kislova A. A. Petrenko M. P. Kostinov E. A. Nikitin Vaccination in Patients with Chronic Lymphocytic Leukemia: Current Problems Эпидемиология и вакцинопрофилактика сhronic lymphocytic leukemia secondary immunodeficiency vaccination pneumococcal vaccination influenza vaccination antibody failure |
author_facet |
M. I. Kislova A. A. Petrenko M. P. Kostinov E. A. Nikitin |
author_sort |
M. I. Kislova |
title |
Vaccination in Patients with Chronic Lymphocytic Leukemia: Current Problems |
title_short |
Vaccination in Patients with Chronic Lymphocytic Leukemia: Current Problems |
title_full |
Vaccination in Patients with Chronic Lymphocytic Leukemia: Current Problems |
title_fullStr |
Vaccination in Patients with Chronic Lymphocytic Leukemia: Current Problems |
title_full_unstemmed |
Vaccination in Patients with Chronic Lymphocytic Leukemia: Current Problems |
title_sort |
vaccination in patients with chronic lymphocytic leukemia: current problems |
publisher |
Numikom LLC |
series |
Эпидемиология и вакцинопрофилактика |
issn |
2073-3046 2619-0494 |
publishDate |
2021-07-01 |
description |
Relevance. Infections are the most common complication of chronic lymphocytic leukemia (CLL). According to registry studies, infections are the cause of death in 10–20% of patients. The emergence of new therapies for CLL has led to a decrease in mortality due to CLL progression, while mortality from infections has remained constant in recent decades.The aim of this literature review is to analyze the effectiveness of vaccine prophylaxis in patients with CLL as well as predictors of vaccine inefficiency according to published data, to explore current guidelines.Conclusions. The mechanisms of immune dysfunction in CLL are complex and associated with both the disease itself and the therapy. Numerous studies have shown that patients with CLL have an inadequate response to most vaccines given routinely in the general population. Vaccination in CLL patients remains a poorly developed topic. Additional clinical trials are needed to improve the effectiveness of vaccination in patients with CLL. |
topic |
сhronic lymphocytic leukemia secondary immunodeficiency vaccination pneumococcal vaccination influenza vaccination antibody failure |
url |
https://www.epidemvac.ru/jour/article/view/1294 |
work_keys_str_mv |
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1721272915482116096 |