Machine learning analyses of antibody somatic mutations predict immunoglobulin light chain toxicity

Machine learning analyses of antibody somatic mutations predict immunoglobulin light chain toxicity

Systemic light chain amyloidosis (AL) is caused by the production of toxic light chains and can be fatal, yet effective treatments are often not possible due to delayed diagnosis. Here the authors show that a machine learning platform analyzing light chain somatic mutations allows the prediction of...

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Bibliographic Details
Main Authors: Maura Garofalo, Luca Piccoli, Margherita Romeo, Maria Monica Barzago, Sara Ravasio, Mathilde Foglierini, Milos Matkovic, Jacopo Sgrignani, Raoul De Gasparo, Marco Prunotto, Luca Varani, Luisa Diomede, Olivier Michielin, Antonio Lanzavecchia, Andrea Cavalli
Format: Article
Language:English
Published: Nature Publishing Group 2021-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-23880-9

Internet

https://doi.org/10.1038/s41467-021-23880-9

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