Palmitoylation of Hedgehog proteins by Hedgehog acyltransferase: roles in signalling and disease
Hedgehog acyltransferase (Hhat), a member of the membrane-bound O-acyltransferase (MBOAT) family, catalyses the covalent attachment of palmitate to the N-terminus of Hedgehog proteins. Palmitoylation is a post-translational modification essential for Hedgehog signalling. This review explores the mec...
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
The Royal Society
2021-03-01
|
| Series: | Open Biology |
| Subjects: | |
| Online Access: | https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.200414 |