Primary Signet-Ring Cell Adenocarcinoma of the Urinary Bladder Treated with Partial Cystectomy: A Case Report and Review of the Literature

Primary signet-ring cell carcinoma is a variant of adenocarcinoma which is extremely rare, associated with poor prognosis and generally found to be resistant to chemotherapy and radiotherapy. We report a case of primary signet-ring cell carcinoma of the bladder which was successfully treated with pa...

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Main Authors: Umesh Jayarajah, D. M. Hilary Fernando, Kasun Bandara Herath, M. V. Chandu de Silva, S. A. S. Goonewardena
Format: Article
Language:English
Published: Hindawi Limited 2017-01-01
Series:Case Reports in Urology
Online Access:http://dx.doi.org/10.1155/2017/6829692
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spelling doaj-5908727bd2a749c497b68f3dadb664232020-11-24T23:06:03ZengHindawi LimitedCase Reports in Urology2090-696X2090-69782017-01-01201710.1155/2017/68296926829692Primary Signet-Ring Cell Adenocarcinoma of the Urinary Bladder Treated with Partial Cystectomy: A Case Report and Review of the LiteratureUmesh Jayarajah0D. M. Hilary Fernando1Kasun Bandara Herath2M. V. Chandu de Silva3S. A. S. Goonewardena4Department of Urology, National Hospital of Sri Lanka, Colombo, Sri LankaDepartment of Urology, National Hospital of Sri Lanka, Colombo, Sri LankaDepartment of Urology, National Hospital of Sri Lanka, Colombo, Sri LankaDepartment of Pathology, Faculty of Medicine, University of Colombo, Colombo, Sri LankaDepartment of Urology, National Hospital of Sri Lanka, Colombo, Sri LankaPrimary signet-ring cell carcinoma is a variant of adenocarcinoma which is extremely rare, associated with poor prognosis and generally found to be resistant to chemotherapy and radiotherapy. We report a case of primary signet-ring cell carcinoma of the bladder which was successfully treated with partial cystectomy. A 71-year-old female with a history of type 2 diabetes, hypertension, and ischaemic heart disease presented with painless haematuria for 2 months’ duration. The abdominal ultrasonography showed a localised polypoidal vesical growth arising from the bladder dome. Cystoscopy revealed an exophytic solid tumour in the anterior fundal wall. A deep transurethral resection of bladder tumour was done and histology revealed an adenocarcinoma composed of mucinous and signet-ring cell components. Later, considering the patient’s age and the poor general condition, a partial cystectomy was done. Follow-up cystoscopy and ultrasonography were done at 12 months and there was no evidence of tumour recurrence and the patient is currently symptom-free. Partial cystectomy may be considered in patients with localised tumour without evidence of metastasis and poor general condition. Regular cystoscopies and ultrasound imaging are necessary for follow-up and early identification of recurrences.http://dx.doi.org/10.1155/2017/6829692
collection DOAJ
language English
format Article
sources DOAJ
author Umesh Jayarajah
D. M. Hilary Fernando
Kasun Bandara Herath
M. V. Chandu de Silva
S. A. S. Goonewardena
spellingShingle Umesh Jayarajah
D. M. Hilary Fernando
Kasun Bandara Herath
M. V. Chandu de Silva
S. A. S. Goonewardena
Primary Signet-Ring Cell Adenocarcinoma of the Urinary Bladder Treated with Partial Cystectomy: A Case Report and Review of the Literature
Case Reports in Urology
author_facet Umesh Jayarajah
D. M. Hilary Fernando
Kasun Bandara Herath
M. V. Chandu de Silva
S. A. S. Goonewardena
author_sort Umesh Jayarajah
title Primary Signet-Ring Cell Adenocarcinoma of the Urinary Bladder Treated with Partial Cystectomy: A Case Report and Review of the Literature
title_short Primary Signet-Ring Cell Adenocarcinoma of the Urinary Bladder Treated with Partial Cystectomy: A Case Report and Review of the Literature
title_full Primary Signet-Ring Cell Adenocarcinoma of the Urinary Bladder Treated with Partial Cystectomy: A Case Report and Review of the Literature
title_fullStr Primary Signet-Ring Cell Adenocarcinoma of the Urinary Bladder Treated with Partial Cystectomy: A Case Report and Review of the Literature
title_full_unstemmed Primary Signet-Ring Cell Adenocarcinoma of the Urinary Bladder Treated with Partial Cystectomy: A Case Report and Review of the Literature
title_sort primary signet-ring cell adenocarcinoma of the urinary bladder treated with partial cystectomy: a case report and review of the literature
publisher Hindawi Limited
series Case Reports in Urology
issn 2090-696X
2090-6978
publishDate 2017-01-01
description Primary signet-ring cell carcinoma is a variant of adenocarcinoma which is extremely rare, associated with poor prognosis and generally found to be resistant to chemotherapy and radiotherapy. We report a case of primary signet-ring cell carcinoma of the bladder which was successfully treated with partial cystectomy. A 71-year-old female with a history of type 2 diabetes, hypertension, and ischaemic heart disease presented with painless haematuria for 2 months’ duration. The abdominal ultrasonography showed a localised polypoidal vesical growth arising from the bladder dome. Cystoscopy revealed an exophytic solid tumour in the anterior fundal wall. A deep transurethral resection of bladder tumour was done and histology revealed an adenocarcinoma composed of mucinous and signet-ring cell components. Later, considering the patient’s age and the poor general condition, a partial cystectomy was done. Follow-up cystoscopy and ultrasonography were done at 12 months and there was no evidence of tumour recurrence and the patient is currently symptom-free. Partial cystectomy may be considered in patients with localised tumour without evidence of metastasis and poor general condition. Regular cystoscopies and ultrasound imaging are necessary for follow-up and early identification of recurrences.
url http://dx.doi.org/10.1155/2017/6829692
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