Fasudil improves survival and promotes skeletal muscle development in a mouse model of spinal muscular atrophy

Fasudil improves survival and promotes skeletal muscle development in a mouse model of spinal muscular atrophy

<p>Abstract</p> <p>Background</p> <p>Spinal muscular atrophy (SMA) is the leading genetic cause of infant death. It is caused by mutations/deletions of the survival motor neuron 1 (<it>SMN1</it>) gene and is typified by the loss of spinal cord motor neurons,...

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Bibliographic Details
Main Authors: Bowerman Melissa, Murray Lyndsay M, Boyer Justin G, Anderson Carrie L, Kothary Rashmi
Format: Article
Language:English
Published: BMC 2012-03-01
Series:BMC Medicine
Subjects:
spinal muscular atrophy
fasudil
survival motor neuron protein
NMJ
muscle
Online Access:http://www.biomedcentral.com/1741-7015/10/24

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http://www.biomedcentral.com/1741-7015/10/24

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