Initiation of HIV Reverse Transcription: Is Enzyme Flipping Required?
Liu and colleagues have recently studied dynamic changes in the orientation of HIV reverse transcriptase (RT) on its nucleic acid substrate during initiation of DNA synthesis. The authors employed a single molecule FRET assay and revealed the existence of an equilibrium between polymerase-competent...
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| Format: | Article |
| Language: | English |
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MDPI AG
2011-04-01
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| Series: | Viruses |
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| Online Access: | http://www.mdpi.com/1999-4915/3/4/331/ |