Human Alpha-1-Antitrypsin (hAAT) therapy reduces renal dysfunction and acute tubular necrosis in a murine model of bilateral kidney ischemia-reperfusion injury.

Human Alpha-1-Antitrypsin (hAAT) therapy reduces renal dysfunction and acute tubular necrosis in a murine model of bilateral kidney ischemia-reperfusion injury.

Several lines of evidence have demonstrated the anti-inflammatory and cytoprotective effects of alpha-1-antitrypsin (AAT), the major serum serine protease inhibitor. The aim of the present study was to investigate the effects of human AAT (hAAT) monotherapy during the early and recovery phase of isc...

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Bibliographic Details
Main Authors: Nuria Maicas, Johan van der Vlag, Janin Bublitz, Sandrine Florquin, Marinka Bakker-van Bebber, Charles A Dinarello, Vivienne Verweij, Roos Masereeuw, Leo A Joosten, Luuk B Hilbrands
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5325207?pdf=render

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http://europepmc.org/articles/PMC5325207?pdf=render

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