Risk of Developing Pancreatic Cancer in Patients with Chronic Pancreatitis
<b>Background</b>: Patients with chronic pancreatitis (CP) have an increased risk of developing pancreatic ductal adenocarcinoma (PDAC). We present data on PDAC in one of the most extensive European single-centre cohort studies of patients with CP. <b>Methods: </b>Retrospecti...
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doaj-5a284b67887f44c8b32ec60bbdd538f02020-11-25T04:00:25ZengMDPI AGJournal of Clinical Medicine2077-03832020-11-0193720372010.3390/jcm9113720Risk of Developing Pancreatic Cancer in Patients with Chronic PancreatitisMiroslav Vujasinovic0Ana Dugic1Patrick Maisonneuve2Amer Aljic3Robin Berggren4Nikola Panic5Roberto Valente6Raffaella Pozzi Mucelli7Alexander Waldthaler8Poya Ghorbani9Maximilian Kordes10Hannes Hagström11J.-Matthias Löhr12Department of Upper Abdominal Diseases, Karolinska University Hospital, 14186 Stockholm, SwedenDepartment of Medicine, Huddinge, Karolinska Institutet, 14186 Stockholm, SwedenDivision of Epidemiology and Biostatistics, IEO, European Institute of Oncology IRCCS, 20141 Milan, ItalyDepartment of Medicine, Huddinge, Karolinska Institutet, 14186 Stockholm, SwedenDepartment of Medicine, Huddinge, Karolinska Institutet, 14186 Stockholm, SwedenDepartment of Upper Abdominal Diseases, Karolinska University Hospital, 14186 Stockholm, SwedenDepartment of Medicine, Huddinge, Karolinska Institutet, 14186 Stockholm, SwedenDepartment of Clinical Science, Intervention, and Technology (CLINTEC), Karolinska Institutet, 14186 Stockholm, SwedenDepartment of Upper Abdominal Diseases, Karolinska University Hospital, 14186 Stockholm, SwedenDepartment of Upper Abdominal Diseases, Karolinska University Hospital, 14186 Stockholm, SwedenDepartment of Upper Abdominal Diseases, Karolinska University Hospital, 14186 Stockholm, SwedenDepartment of Upper Abdominal Diseases, Karolinska University Hospital, 14186 Stockholm, SwedenDepartment of Upper Abdominal Diseases, Karolinska University Hospital, 14186 Stockholm, Sweden<b>Background</b>: Patients with chronic pancreatitis (CP) have an increased risk of developing pancreatic ductal adenocarcinoma (PDAC). We present data on PDAC in one of the most extensive European single-centre cohort studies of patients with CP. <b>Methods: </b>Retrospective analysis of prospectively collected data of patients with CP was performed. Aetiology of CP was determined according to the M-ANNHEIM classification system and only patients with definite CP > 18 years at data analysis were included. The final dataset included 581 patients with definite CP diagnosed between 2003 and 2018. <b>Results: </b>At CP diagnosis, there were 371 (63.9%) males and 210 (36.1%) females (median age 57 years, range 2–86). During 3423 person-years of observation, six pancreatic cancers were diagnosed (0.2% year). The mean time between diagnosis of CP and the occurrence of PDAC was 5.0 years (range 2.7–8.6). None of the cancer patients had a family history of PDAC. Diabetes mellitus (DM) was present in five of six (83.3%) patients with PDAC: in three patients before and in two after CP diagnosis. Clinical/laboratory signs of pancreatic exocrine insufficiency (PEI) were present in five of six (83.3%) patients with PDAC: in two at diagnosis of CP and in three after diagnosis. The mean survival time was 4 months after the diagnosis of PDAC (range 0.5–13). PDAC occurred significantly more often (<i>p</i> < 0.001) in two groups of patients without previous acute pancreatitis (AP): 2 of 20 patients (10%) with low body mass index (BMI) and PEI and in 3 of 10 (30%) patients with high BMI and DM at diagnosis of CP. <b>Conclusions: </b>Patients with CP have a high risk of developing PDAC, although risk is low in absolute terms. Our data suggest the possibility of defining subgroups of patients with a particularly elevated risk of PDAC. Such a possibility would open a path to personalised decision making on initiation of PDAC surveillance of patients with no previous episode of AP, (i) with low BMI and PEI, or (ii) elevated BMI and DM.https://www.mdpi.com/2077-0383/9/11/3720pancreascancerchronic pancreatitisrisk factors |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Miroslav Vujasinovic Ana Dugic Patrick Maisonneuve Amer Aljic Robin Berggren Nikola Panic Roberto Valente Raffaella Pozzi Mucelli Alexander Waldthaler Poya Ghorbani Maximilian Kordes Hannes Hagström J.-Matthias Löhr |
spellingShingle |
Miroslav Vujasinovic Ana Dugic Patrick Maisonneuve Amer Aljic Robin Berggren Nikola Panic Roberto Valente Raffaella Pozzi Mucelli Alexander Waldthaler Poya Ghorbani Maximilian Kordes Hannes Hagström J.-Matthias Löhr Risk of Developing Pancreatic Cancer in Patients with Chronic Pancreatitis Journal of Clinical Medicine pancreas cancer chronic pancreatitis risk factors |
author_facet |
Miroslav Vujasinovic Ana Dugic Patrick Maisonneuve Amer Aljic Robin Berggren Nikola Panic Roberto Valente Raffaella Pozzi Mucelli Alexander Waldthaler Poya Ghorbani Maximilian Kordes Hannes Hagström J.-Matthias Löhr |
author_sort |
Miroslav Vujasinovic |
title |
Risk of Developing Pancreatic Cancer in Patients with Chronic Pancreatitis |
title_short |
Risk of Developing Pancreatic Cancer in Patients with Chronic Pancreatitis |
title_full |
Risk of Developing Pancreatic Cancer in Patients with Chronic Pancreatitis |
title_fullStr |
Risk of Developing Pancreatic Cancer in Patients with Chronic Pancreatitis |
title_full_unstemmed |
Risk of Developing Pancreatic Cancer in Patients with Chronic Pancreatitis |
title_sort |
risk of developing pancreatic cancer in patients with chronic pancreatitis |
publisher |
MDPI AG |
series |
Journal of Clinical Medicine |
issn |
2077-0383 |
publishDate |
2020-11-01 |
description |
<b>Background</b>: Patients with chronic pancreatitis (CP) have an increased risk of developing pancreatic ductal adenocarcinoma (PDAC). We present data on PDAC in one of the most extensive European single-centre cohort studies of patients with CP. <b>Methods: </b>Retrospective analysis of prospectively collected data of patients with CP was performed. Aetiology of CP was determined according to the M-ANNHEIM classification system and only patients with definite CP > 18 years at data analysis were included. The final dataset included 581 patients with definite CP diagnosed between 2003 and 2018. <b>Results: </b>At CP diagnosis, there were 371 (63.9%) males and 210 (36.1%) females (median age 57 years, range 2–86). During 3423 person-years of observation, six pancreatic cancers were diagnosed (0.2% year). The mean time between diagnosis of CP and the occurrence of PDAC was 5.0 years (range 2.7–8.6). None of the cancer patients had a family history of PDAC. Diabetes mellitus (DM) was present in five of six (83.3%) patients with PDAC: in three patients before and in two after CP diagnosis. Clinical/laboratory signs of pancreatic exocrine insufficiency (PEI) were present in five of six (83.3%) patients with PDAC: in two at diagnosis of CP and in three after diagnosis. The mean survival time was 4 months after the diagnosis of PDAC (range 0.5–13). PDAC occurred significantly more often (<i>p</i> < 0.001) in two groups of patients without previous acute pancreatitis (AP): 2 of 20 patients (10%) with low body mass index (BMI) and PEI and in 3 of 10 (30%) patients with high BMI and DM at diagnosis of CP. <b>Conclusions: </b>Patients with CP have a high risk of developing PDAC, although risk is low in absolute terms. Our data suggest the possibility of defining subgroups of patients with a particularly elevated risk of PDAC. Such a possibility would open a path to personalised decision making on initiation of PDAC surveillance of patients with no previous episode of AP, (i) with low BMI and PEI, or (ii) elevated BMI and DM. |
topic |
pancreas cancer chronic pancreatitis risk factors |
url |
https://www.mdpi.com/2077-0383/9/11/3720 |
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