Polypeptide Modulators of TRPV1 Produce Analgesia without Hyperthermia

Polypeptide Modulators of TRPV1 Produce Analgesia without Hyperthermia

Transient receptor potential vanilloid 1 receptors (TRPV1) play a significant physiological role. The study of novel TRPV1 agonists and antagonists is essential. Here, we report on the characterization of polypeptide antagonists of TRPV1 based on in vitro and in vivo experiments. We evaluated the ab...

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Bibliographic Details
Main Authors: Yaroslav A. Andreev, Sergey A. Kozlov, Yuliya V. Korolkova, Igor A. Dyachenko, Dmitrii A. Bondarenko, Denis I. Skobtsov, Arkadii N. Murashev, Polina D. Kotova, Olga A. Rogachevskaja, Natalia V. Kabanova, Stanislav S. Kolesnikov, Eugene V. Grishin
Format: Article
Language:English
Published: MDPI AG 2013-12-01
Series:Marine Drugs
Subjects:
sea anemone
analgesic polypeptide APHC
TRPV1 receptor
animal models
temperature regulation
nociception
inflammation
Online Access:http://www.mdpi.com/1660-3397/11/12/5100

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http://www.mdpi.com/1660-3397/11/12/5100

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