Interaction between ERAP Alleles and HLA Class I Types Support a Role of Antigen Presentation in Hodgkin Lymphoma Development

Interaction between ERAP Alleles and HLA Class I Types Support a Role of Antigen Presentation in Hodgkin Lymphoma Development

Genetic variants in the HLA region are the strongest risk factors for developing Hodgkin lymphoma (HL), suggesting an important role for antigen presentation. This is supported by another HL-associated genomic region which contains the loci of two enzymes that process endogenous proteins to peptides...

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Bibliographic Details
Main Authors: Peijia Jiang, Rianne N. Veenstra, Annika Seitz, Ilja M. Nolte, Bouke G. Hepkema, Lydia Visser, Anke van den Berg, Arjan Diepstra
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:Cancers
Subjects:
Hodgkin lymphoma
<i>ERAP1</i>
<i>ERAP2</i>
SNP
HLA class I
susceptibility
Online Access:https://www.mdpi.com/2072-6694/13/3/414

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