A study of the evolution of human microRNAs by their apparent repression effectiveness on target genes.

BACKGROUND: Even though the genomes of many model species have already been sequenced, our knowledge of gene regulation in evolution is still very limited. One big obstacle is that it is hard to predict the target genes of transcriptional factors accurately from sequences. In this respect, microRNAs...

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Bibliographic Details
Main Authors: Yong Huang, Xun Gu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3177854?pdf=render