The Origins of Gastric Cancer From Gastric Stem Cells: Lessons From Mouse ModelsSummary

The Origins of Gastric Cancer From Gastric Stem Cells: Lessons From Mouse ModelsSummary

The cellular origin of digestive cancers has been a long-standing question in the cancer field. Mouse models have identified long-lived stem cells in most organ systems, including the luminal gastrointestinal tract, and numerous studies have pointed to tissue resident stem cells as the main cellular...

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Main Authors: Yoku Hayakawa, James G. Fox, Timothy C. Wang
Format: Article
Language:English
Published: Elsevier 2017-05-01
Series:Cellular and Molecular Gastroenterology and Hepatology
Online Access:http://www.sciencedirect.com/science/article/pii/S2352345X17300310
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spelling doaj-5bc83b6df17a449194d0207b7dd2dd4c2020-11-25T00:36:43ZengElsevierCellular and Molecular Gastroenterology and Hepatology2352-345X2017-05-0133331338The Origins of Gastric Cancer From Gastric Stem Cells: Lessons From Mouse ModelsSummaryYoku Hayakawa0James G. Fox1Timothy C. Wang2Department of Gastroenterology, Graduate School of Medicine, University of Tokyo, Tokyo, JapanDivision of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MassachusettsDivision of Digestive and Liver Diseases, Department of Medicine, Columbia University, New York, New York; Correspondence Address correspondence to: Timothy C. Wang, MD, Division of Digestive and Liver Diseases, Department of Medicine and Irving Cancer Research Center, Columbia University Medical Center, 1130 St Nicholas Avenue, Room 925, New York, New York 10032-3802. fax: (212) 851-4590.The cellular origin of digestive cancers has been a long-standing question in the cancer field. Mouse models have identified long-lived stem cells in most organ systems, including the luminal gastrointestinal tract, and numerous studies have pointed to tissue resident stem cells as the main cellular origin of cancer. During gastric carcinogenesis, chronic inflammation induces genetic and epigenetic alterations in long-lived stem cells, along with expansion of stem cell niches, eventually leading to invasive cancer. The gastric corpus and antrum have distinct stem cells and stem cell niches, suggesting differential regulation of cancer initiation at the 2 sites. In this short review, we discuss recent experimental models and human studies, which provide important insights into the pathogenesis of gastric cancer. Keywords: Gastric Cancer, Stem Cell, Stem Cell Niche, Lgr5, Mist1, CCK2Rhttp://www.sciencedirect.com/science/article/pii/S2352345X17300310
collection DOAJ
language English
format Article
sources DOAJ
author Yoku Hayakawa
James G. Fox
Timothy C. Wang
spellingShingle Yoku Hayakawa
James G. Fox
Timothy C. Wang
The Origins of Gastric Cancer From Gastric Stem Cells: Lessons From Mouse ModelsSummary
Cellular and Molecular Gastroenterology and Hepatology
author_facet Yoku Hayakawa
James G. Fox
Timothy C. Wang
author_sort Yoku Hayakawa
title The Origins of Gastric Cancer From Gastric Stem Cells: Lessons From Mouse ModelsSummary
title_short The Origins of Gastric Cancer From Gastric Stem Cells: Lessons From Mouse ModelsSummary
title_full The Origins of Gastric Cancer From Gastric Stem Cells: Lessons From Mouse ModelsSummary
title_fullStr The Origins of Gastric Cancer From Gastric Stem Cells: Lessons From Mouse ModelsSummary
title_full_unstemmed The Origins of Gastric Cancer From Gastric Stem Cells: Lessons From Mouse ModelsSummary
title_sort origins of gastric cancer from gastric stem cells: lessons from mouse modelssummary
publisher Elsevier
series Cellular and Molecular Gastroenterology and Hepatology
issn 2352-345X
publishDate 2017-05-01
description The cellular origin of digestive cancers has been a long-standing question in the cancer field. Mouse models have identified long-lived stem cells in most organ systems, including the luminal gastrointestinal tract, and numerous studies have pointed to tissue resident stem cells as the main cellular origin of cancer. During gastric carcinogenesis, chronic inflammation induces genetic and epigenetic alterations in long-lived stem cells, along with expansion of stem cell niches, eventually leading to invasive cancer. The gastric corpus and antrum have distinct stem cells and stem cell niches, suggesting differential regulation of cancer initiation at the 2 sites. In this short review, we discuss recent experimental models and human studies, which provide important insights into the pathogenesis of gastric cancer. Keywords: Gastric Cancer, Stem Cell, Stem Cell Niche, Lgr5, Mist1, CCK2R
url http://www.sciencedirect.com/science/article/pii/S2352345X17300310
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