The chaperone-binding activity of the mitochondrial surface receptor Tom70 protects the cytosol against mitoprotein-induced stress

The chaperone-binding activity of the mitochondrial surface receptor Tom70 protects the cytosol against mitoprotein-induced stress

Summary: Most mitochondrial proteins are synthesized as precursors in the cytosol and post-translationally transported into mitochondria. The mitochondrial surface protein Tom70 acts at the interface of the cytosol and mitochondria. In vitro import experiments identified Tom70 as targeting receptor,...

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Bibliographic Details
Main Authors: Sandra Backes, Yury S. Bykov, Tamara Flohr, Markus Räschle, Jialin Zhou, Svenja Lenhard, Lena Krämer, Timo Mühlhaus, Chen Bibi, Cosimo Jann, Justin D. Smith, Lars M. Steinmetz, Doron Rapaport, Zuzana Storchová, Maya Schuldiner, Felix Boos, Johannes M. Herrmann
Format: Article
Language:English
Published: Elsevier 2021-04-01
Series:Cell Reports
Subjects:
chaperones
mitochondria
outer membrane
proteostasis
prototoxicity
Tom70
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721002503

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http://www.sciencedirect.com/science/article/pii/S2211124721002503

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