Establishment and validation of an endoplasmic reticulum stress reporter to monitor zebrafish ATF6 activity in development and disease

Establishment and validation of an endoplasmic reticulum stress reporter to monitor zebrafish ATF6 activity in development and disease

Induction of endoplasmic reticulum (ER) stress is associated with diverse developmental and degenerative diseases. Modified ER homeostasis causes activation of conserved stress pathways at the ER called the unfolded protein response (UPR). ATF6 is a transcription factor activated during ER stress as...

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Bibliographic Details
Main Authors: Eric M. Clark, Hannah J. T. Nonarath, Jonathan R. Bostrom, Brian A. Link
Format: Article
Language:English
Published: The Company of Biologists 2020-01-01
Series:Disease Models & Mechanisms
Subjects:
atf6
endoplasmic reticulum stress
unfolded protein response
zebrafish
neurodegeneration
Online Access:http://dmm.biologists.org/content/13/1/dmm041426

Internet

http://dmm.biologists.org/content/13/1/dmm041426

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