Cholesterol Sequestration from Caveolae/Lipid Rafts Enhances Cationic Liposome-Mediated Nucleic Acid Delivery into Endothelial Cells

Cholesterol Sequestration from Caveolae/Lipid Rafts Enhances Cationic Liposome-Mediated Nucleic Acid Delivery into Endothelial Cells

Delivering nucleic acids into the endothelium has great potential in treating vascular diseases. However, endothelial cells, which line the vasculature, are considered as sensitive in nature and hard to transfect. Low transfection efficacies in endothelial cells limit their potential therapeutic app...

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Bibliographic Details
Main Authors: Santhosh Chandar Maddila, Chandrashekhar Voshavar, Porkizhi Arjunan, Rashmi Prakash Chowath, Hari Krishna Reddy Rachamalla, Balaji Balakrishnan, Poonkuzhali Balasubramanian, Rajkumar Banerjee, Srujan Marepally
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Molecules
Subjects:
cationic lipids
clathrin-mediated endocytosis
caveolae-mediated endocytosis
macropinocytosis
transfection
endothelial cells
Online Access:https://www.mdpi.com/1420-3049/26/15/4626

Internet

https://www.mdpi.com/1420-3049/26/15/4626

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