Perturbations in small molecule synthesis uncovers an iron-responsive secondary metabolite network in Aspergillus fumigatus

Perturbations in small molecule synthesis uncovers an iron-responsive secondary metabolite network in Aspergillus fumigatus

Iron plays a critical role in survival and virulence of the opportunistic pathogen Aspergillus fumigatus. Two transcription factors, the GATA-factor SreA and the bZip-factor HapX oppositely monitor iron homeostasis with HapX activating iron acquisition pathways (e.g. siderophores) and shutting down...

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Bibliographic Details
Main Authors: Philipp eWiemann, Beatrix E. Lechner, Joshua A. Baccile, Thomas A. Velk, Wen-Bing eYin, Jin Woo eBok, Liliana eLosada, Suman ePakala, William C. Nierman, Frank C. Schroeder, Hubertus eHaas, Nancy P. Keller
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-10-01
Series:Frontiers in Microbiology
Subjects:
Aspergillus fumigatus
Iron
gene regulation
secondary metabolism
HapX
SreA
Online Access:http://journal.frontiersin.org/Journal/10.3389/fmicb.2014.00530/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fmicb.2014.00530/full

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