Nrf2 is overexpressed in pancreatic cancer: implications for cell proliferation and therapy
<p>Abstract</p> <p>Background</p> <p>Nrf2 is a key transcriptional regulator of a battery of genes that facilitate phase II/III drug metabolism and defence against oxidative stress. Nrf2 is largely regulated by Keap1, which directs Nrf2 for proteasomal degradation. The...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2011-04-01
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| Series: | Molecular Cancer |
| Online Access: | http://www.molecular-cancer.com/content/10/1/37 |