Topoisomerase IIbeta activates a subset of neuronal genes that are repressed in AT-rich genomic environment.
DNA topoisomerase II (topo II) catalyzes a strand passage reaction in that one duplex is passed through a transient brake or gate in another. Completion of late stages of neuronal development depends on the presence of active beta isoform (topo IIbeta). The enzyme appears to aid the transcriptional...
Main Authors: | Kuniaki Sano, Mary Miyaji-Yamaguchi, Kimiko M Tsutsui, Ken Tsutsui |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2008-01-01
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Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC2605559?pdf=render |
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