Functional Genome-wide Screen Identifies Pathways Restricting Central Nervous System Axonal Regeneration

Functional Genome-wide Screen Identifies Pathways Restricting Central Nervous System Axonal Regeneration

Summary: Axonal regrowth is crucial for recovery from CNS injury but is severely restricted in adult mammals. We used a genome-wide loss-of-function screen for factors limiting axonal regeneration from cerebral cortical neurons in vitro. Knockdown of 16,007 individual genes identified 580 significan...

Full description

Bibliographic Details
Main Authors: Yuichi Sekine, Alexander Lin-Moore, Devon M. Chenette, Xingxing Wang, Zhaoxin Jiang, William B. Cafferty, Marc Hammarlund, Stephen M. Strittmatter
Format: Article
Language:English
Published: Elsevier 2018-04-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124718304030

Internet

http://www.sciencedirect.com/science/article/pii/S2211124718304030

Similar Items