HIV-1 Tat phosphorylation on Ser-16 residue modulates HIV-1 transcription

HIV-1 Tat phosphorylation on Ser-16 residue modulates HIV-1 transcription

Abstract Background HIV-1 transcription activator protein Tat is phosphorylated in vitro by CDK2 and DNA-PK on Ser-16 residue and by PKR on Tat Ser-46 residue. Here we analyzed Tat phosphorylation in cultured cells and its functionality. Results Mass spectrometry analysis showed primarily Tat Ser-16...

Full description

Bibliographic Details
Main Authors: Andrey Ivanov, Xionghao Lin, Tatiana Ammosova, Andrey V. Ilatovskiy, Namita Kumari, Hatajai Lassiter, Nowah Afangbedji, Xiaomei Niu, Michael G. Petukhov, Sergei Nekhai
Format: Article
Language:English
Published: BMC 2018-05-01
Series:Retrovirology
Online Access:http://link.springer.com/article/10.1186/s12977-018-0422-5

Internet

http://link.springer.com/article/10.1186/s12977-018-0422-5

Similar Items