Synthesis of New Indanyl Nucleoside Analogues and their Biological Evaluation on Hepatitis C Virus (HCV) Replicon

Synthesis of New Indanyl Nucleoside Analogues and their Biological Evaluation on Hepatitis C Virus (HCV) Replicon

Here, we report a convenient synthetic procedure for the preparation of four novel indanyl carbanucleoside derivatives in the racemic form. The action of these compounds against hepatitis C virus was evaluated in vitro using the replicon cell line, Huh7.5 SG. Contrary to our expectations, all these...

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Bibliographic Details
Main Authors: Matías E. Gómez, Emiliano A. Gentile, M. Florencia Martini, María L. Cuestas, Verónica L. Mathet, Graciela Y. Moltrasio, Albertina G. Moglioni
Format: Article
Language:English
Published: MDPI AG 2019-03-01
Series:Molecules
Subjects:
nucleoside analogues
cis-2-amino-1-indanol
HCV replicon
molecular modeling
Online Access:http://www.mdpi.com/1420-3049/24/5/990

Internet

http://www.mdpi.com/1420-3049/24/5/990

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