Inhibition of CYP2B6 by Medicinal Plant Extracts: Implication for Use of Efavirenz and Nevirapine-Based Highly Active Anti-Retroviral Therapy (HAART) in Resource-Limited Settings

Inhibition of CYP2B6 by Medicinal Plant Extracts: Implication for Use of Efavirenz and Nevirapine-Based Highly Active Anti-Retroviral Therapy (HAART) in Resource-Limited Settings

Highly active antiretroviral therapy (HAART) has greatly improved health parameters of HIV infected individuals. However, there are several challenges associated with the chronic nature of HAART administration. For populations in health transition, dual use of medicinal plant extracts and convention...

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Bibliographic Details
Main Authors: Nicholas E. Thomford, Charles Awortwe, Kevin Dzobo, Faustina Adu, Denis Chopera, Ambroise Wonkam, Michelle Skelton, Dee Blackhurst, Collet Dandara
Format: Article
Language:English
Published: MDPI AG 2016-02-01
Series:Molecules
Subjects:
herb-drug interactions
CYP450
time-dependent inhibition
reversible inhibition
recombinant human CYPs
Online Access:http://www.mdpi.com/1420-3049/21/2/211

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http://www.mdpi.com/1420-3049/21/2/211

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