Proteinuria may be an indicator of adverse pregnancy outcomes in patients with preeclampsia: a retrospective study
Abstract Background Proteinuria is one of the common manifestations of patients with preeclampsia (PE), but whether the severity of proteinuria is related to the pregnancy outcome of patients with preeclampsia remains controversial. The present study aimed to determine the relationship between 24-h...
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doaj-5dcc315b046748aaa32881a00997d9e42021-05-16T11:08:40ZengBMCReproductive Biology and Endocrinology1477-78272021-05-011911810.1186/s12958-021-00751-yProteinuria may be an indicator of adverse pregnancy outcomes in patients with preeclampsia: a retrospective studyTingting Lei0Ting Qiu1Wanyu Liao2Kangjie Li3Xinyue Lai4Hongbo Huang5Rui Yuan6Ling Chen7First Clinical College, Chongqing Medical UniversityFirst Clinical College, Chongqing Medical UniversityFirst Clinical College, Chongqing Medical UniversitySchool of Public Health and Management, Chongqing Medical UniversityFirst Clinical College, Chongqing Medical UniversitySecond Clinical College, Chongqing Medical UniversityChongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment, Chongqing Univ-ersity Cancer Hospital & Chongqing Cancer Institute & Chongqing Cancer HospitalThe Center of Experimental Teaching Management, Chongqing Medical UniversityAbstract Background Proteinuria is one of the common manifestations of patients with preeclampsia (PE), but whether the severity of proteinuria is related to the pregnancy outcome of patients with preeclampsia remains controversial. The present study aimed to determine the relationship between 24-h proteinuria and adverse outcomes in patients with preeclampsia. Methods The present retrospective study included 329 pregnant women in Chongqing, China. Patients were divided into PE group and non-PE group. PE group was stratified into three subgroups based on the level of 24-h proteinuria. Correlation analysis was used to analyze the correlation between biochemical indexes and adverse pregnancy outcome, and Logistic regression analysis was used to analyze the risk factors of adverse pregnancy outcome. The receiver operating characteristic curve (ROC) was used to evaluate the ability of 24-h urinary protein to distinguish the adverse pregnancy outcome in patients with preeclampsia. Results (1) Between PE and non-PE group, cesarean section rate in PE group was significantly higher than that in non-PE group (84.4% vs. 25.9%, p < 0.001). Laboratory findings such as uric acid and creatinine level in PE group were higher than those in non-PE group. (2) Among mild (proteinuria < 0.3 g/24 h), moderate (0.3 g/24 h ≦ proteinuria < 2 g/24 h) and massive (proteinuria ≧ 2 g/24 h) groups, the frequencies of induced labor (p = 0.006) and stillbirth (p = 0.002) increased with the increase of 24-h proteinuria. (3) Adverse outcomes were positively correlated with 24-h proteinuria (adverse maternal outcomes: r = 0.239, p = 0.002; adverse fetal outcomes: r = 0.336, p < 0.001). (4) The best 24-h proteinuria cutoff values to determine stillbirth, premature and fetal distress were 3965.0 mg/24 h, 984.75 mg/24 h and 1503.85 mg/24 h and their odds ratio (95% confidence interval) were 12.46 (3.46–44.88), 2.48 (1.15–5.37) and 10.02 (2.14–46.80), respectively. Conclusions The severity of 24-h proteinuia may forecast adverse outcomes in women with preeclampsia. We suggest proteinuria should be retained as one of the monitoring indexes in patients with preeclampsia. Trial registration Retrospectively registered. (LTMCMTS202001).https://doi.org/10.1186/s12958-021-00751-yPreeclampsiaProteinuriaPregnancy complicationsNeonatal outcomeGestational hypertension |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Tingting Lei Ting Qiu Wanyu Liao Kangjie Li Xinyue Lai Hongbo Huang Rui Yuan Ling Chen |
spellingShingle |
Tingting Lei Ting Qiu Wanyu Liao Kangjie Li Xinyue Lai Hongbo Huang Rui Yuan Ling Chen Proteinuria may be an indicator of adverse pregnancy outcomes in patients with preeclampsia: a retrospective study Reproductive Biology and Endocrinology Preeclampsia Proteinuria Pregnancy complications Neonatal outcome Gestational hypertension |
author_facet |
Tingting Lei Ting Qiu Wanyu Liao Kangjie Li Xinyue Lai Hongbo Huang Rui Yuan Ling Chen |
author_sort |
Tingting Lei |
title |
Proteinuria may be an indicator of adverse pregnancy outcomes in patients with preeclampsia: a retrospective study |
title_short |
Proteinuria may be an indicator of adverse pregnancy outcomes in patients with preeclampsia: a retrospective study |
title_full |
Proteinuria may be an indicator of adverse pregnancy outcomes in patients with preeclampsia: a retrospective study |
title_fullStr |
Proteinuria may be an indicator of adverse pregnancy outcomes in patients with preeclampsia: a retrospective study |
title_full_unstemmed |
Proteinuria may be an indicator of adverse pregnancy outcomes in patients with preeclampsia: a retrospective study |
title_sort |
proteinuria may be an indicator of adverse pregnancy outcomes in patients with preeclampsia: a retrospective study |
publisher |
BMC |
series |
Reproductive Biology and Endocrinology |
issn |
1477-7827 |
publishDate |
2021-05-01 |
description |
Abstract Background Proteinuria is one of the common manifestations of patients with preeclampsia (PE), but whether the severity of proteinuria is related to the pregnancy outcome of patients with preeclampsia remains controversial. The present study aimed to determine the relationship between 24-h proteinuria and adverse outcomes in patients with preeclampsia. Methods The present retrospective study included 329 pregnant women in Chongqing, China. Patients were divided into PE group and non-PE group. PE group was stratified into three subgroups based on the level of 24-h proteinuria. Correlation analysis was used to analyze the correlation between biochemical indexes and adverse pregnancy outcome, and Logistic regression analysis was used to analyze the risk factors of adverse pregnancy outcome. The receiver operating characteristic curve (ROC) was used to evaluate the ability of 24-h urinary protein to distinguish the adverse pregnancy outcome in patients with preeclampsia. Results (1) Between PE and non-PE group, cesarean section rate in PE group was significantly higher than that in non-PE group (84.4% vs. 25.9%, p < 0.001). Laboratory findings such as uric acid and creatinine level in PE group were higher than those in non-PE group. (2) Among mild (proteinuria < 0.3 g/24 h), moderate (0.3 g/24 h ≦ proteinuria < 2 g/24 h) and massive (proteinuria ≧ 2 g/24 h) groups, the frequencies of induced labor (p = 0.006) and stillbirth (p = 0.002) increased with the increase of 24-h proteinuria. (3) Adverse outcomes were positively correlated with 24-h proteinuria (adverse maternal outcomes: r = 0.239, p = 0.002; adverse fetal outcomes: r = 0.336, p < 0.001). (4) The best 24-h proteinuria cutoff values to determine stillbirth, premature and fetal distress were 3965.0 mg/24 h, 984.75 mg/24 h and 1503.85 mg/24 h and their odds ratio (95% confidence interval) were 12.46 (3.46–44.88), 2.48 (1.15–5.37) and 10.02 (2.14–46.80), respectively. Conclusions The severity of 24-h proteinuia may forecast adverse outcomes in women with preeclampsia. We suggest proteinuria should be retained as one of the monitoring indexes in patients with preeclampsia. Trial registration Retrospectively registered. (LTMCMTS202001). |
topic |
Preeclampsia Proteinuria Pregnancy complications Neonatal outcome Gestational hypertension |
url |
https://doi.org/10.1186/s12958-021-00751-y |
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